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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD)
An International Open Access Journal |   ISSN: 2456-4184 |  IMPACT FACTOR: 5.57

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Paper Title: FORMULATION AND EVALUATION OF ARMODAFINIL SUSTAINED RELEASE TABLETS
Authors Name: SHAKERA SULTANA , H.PADMALATHA
Author Reg. ID:
IJNRD_170184
Published Paper Id: IJNRD1801002
Published In: Volume 3 Issue 1, January-2018
Abstract: Armodafinil is a wake promoting agent, which is used in the treatment of excessive daytime sleepiness arising from narcolepsy, obstructive sleep apnea and shift-work disorders. Therefore the present investigation concerned with the development of once-a-day armodafinil sustained release tablets to extend the duration of action up to 24 hrs by controlling the dissolution rate using different viscosity grades of HPMC. About eight different formulations of armodafinil sustained release tablets were developed by direct compression method using HPMC K4M CR and HPMC K100M CR, as polymers at different ratios and all the formulations were evaluated for their micromeritic properties such as compressibility index, hausner’s ratio and sieve analysis. In-vitro dissolution studies for all the formulations were performed in 0.01M HCL media, which is the ideal media. From the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e. 82% of drug release was observed in 16 hrs & up to 98% in 24 hours. Kinetics to the in-vitro release of drug for the formulation, F-6 showed that it followed first order release (R2 = 0.9686) and release mechanism followed was Hixson Crowell cube root law (R2=0.9816). Further, in-vitro release pattern of drug from the optimized formulation, F-6 was found to be super imposable (i.e. the similarity factor f2 was found to be 81.90) with the marketed product NUVIGIL. The optimized formulation, F-6 was found to be stable during accelerated stability studies conducted at 40°C / 75% RH for three months as per ICH guidelines.
Keywords: Armodafinil; sustained release; once-a-day; HPMC K4M CR; HPMC K100M CR; dissolution.
Cite Article: "FORMULATION AND EVALUATION OF ARMODAFINIL SUSTAINED RELEASE TABLETS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.3, Issue 1, page no.7-12, January-2018, Available :http://www.ijnrd.org/papers/IJNRD1801002.pdf
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