INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Nanostructured lipid carriers of glimepiride (NLC) have been developed for the treatment of type 2 diabetes. The developed NLC consists of Compritol ATO 888 as a solid lipid, medium chain triglycerides as a liquid lipid, and Poloxamer 188 as a surfactant. NLCs were prepared using a hot homogenization method and characterized by FT-IR. All NLCs showed recording efficiency in the range of 78.52 to 90.38%. Both the capture efficiency and the release rate were affected by the lipid concentration. Formulation F5 was considered an optimized formulation based on particle size and percentage of drug release. The zeta potential value indicated good stability of the particles. The optimized formulation showed no physical/chemical changes when exposed to accelerated stability conditions. It was concluded that the developed NLC is a potential approach for controlled medication that can reduce dosing frequency and improve patient compliance.
Keywords:
Glimepiride, hot homogenization technique, Nanocapsule, nanopartical, homogenization
Cite Article:
"Formulation development and evaluation of nanoparticles of Anti-diabetic drug by Hot Homogenization technique", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.e694-e709, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305486.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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