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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Development and validation of RP-HPLC method for simultaneous estimation of Atorvastatin and Irbesartan for combined dosage form |
| Authors Name: | Vijaya M Gaikwad , Vivekanand A Kashid , Kiran B Kotade |
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IJNRD_180338
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| Published Paper Id: | IJNRD2011039 |
| Published In: | Volume 5 Issue 11, November-2020 |
| DOI: | |
| Abstract: | ABSTRACT A specific, precise and accurate RP-HPLC method has been developed for simultaneous estimation of irbesartan and atorvastatin in synthetic mixture. The use of a 250 × 4.6 mm, 5 µm particle size, C18 column with 50: 10: 40 %, v/v/v acetonitrile: methanol: 0.1 % formic acid (pH adjusted to 3.5 with triethylamine) as isocratic mobile phase at flow rate of 1 ml/min enabled separation of drugs. UV detection was performed at 271 nm. The method was validated as per ICH Q2(R1) guidelines. The retention time for irbesartan and atorvastatin were found to be 4.01 ± 0.03 and 7.03 ± 0.03 min respectively. The linearity of method was satisfactory over the range 300-1500 ng (correlation coefficient 0.9993) and 20-100 ng (correlation coefficient 0.9996) for irbesartan and atorvastatin respectively. The limits of detection for irbesartan and atorvastatin were 10.94 and 1.33 ng respectively. The limits of quantitation for irbesartan and atorvastatin were 33.14 and 4.03 ng respectively. Recovery of irbesartan and atorvastatin ranged from 99.84-99.98 % and 99.90-100.67 % respectively. The method was successfully applied to synthetic mixture for quantitative analysis of irbesartan and atorvastatin. Keyword- Irbesartan, Atorvastatin, RP-HPLC, analysis |
| Keywords: | Irbesartan, Atorvastatin, RP-HPLC, UV, Validation |
| Cite Article: | "Development and validation of RP-HPLC method for simultaneous estimation of Atorvastatin and Irbesartan for combined dosage form", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.5, Issue 11, page no.347-391, November-2020, Available :http://www.ijnrd.org/papers/IJNRD2011039.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2011039 Registration ID: 180338 Published In: Volume 5 Issue 11, November-2020 DOI (Digital Object Identifier): Page No: 347-391 Country: Nashik, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2011039 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2011039 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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