FORMULATION AND CHARACTERIZATION OF EUDRAGIT RS 100 NANOSUSPENSION FOR OCULAR DELIVERY OF INDOMETHACIN

Registration ID: IJNRD_181592

Published ID: IJNRD2205180

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SRASHTI KATIYAR, Dr. PANKAJ MISHRA, JEEVAN CHANDRA PANDEY

Introduction, Drug Profile, Experimental Investigation, Drug and Polymer Profile, Summary.

ABSTRACT Several colloidal drug delivery systems were designed to obtain a control release for ophthalmic applications were investigated. These are composed of a polymeric support with or without drug. The drug was normally incorporated as a dispersion or solution in the polymeric support. The main objective of the nano suspension is to increase the contact time of the preparation with conjunctiva tissues so as to ensure a Sustained / Controlled release suited for the topical or systemic treatment. However the details about the preparations and their model of construction are given in many literatures but no specific guideline are mentioned. In the present work, a revival attempts has made us to investigate Indomethacin ocular nano suspension utilizing Eudragit RS 100 as drug reservoir membrane and rate controlling component and its possible utilization in designing and evaluating it for ophthalmic use. All formulations were subjected to various evaluation parameters like identification and compatibility studies of drug and polymer using IR spectrometer and were evaluated for parameters like pH, particle size analysis, drug entrapment efficiency, rheological studies; rabbit eye irritation, in vitro release studies, in vivo drug studies and stability studies. The uniformity of the nano suspension revealed that the drug was uniformly distributed throughout the nano suspension. Increase in the polymer ratio increases the entrapment efficiency of drug which observed by entrapment efficiency studies. Further future work can be progressed to establish the therapeutic utility of these systems by pharmacokinetic and pharmacodynamic studies in human beings. The different Novel Technology can be adopted in the formulation for ophthalmic nano suspensions and thereby investigate their effect on release pattern.

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SRASHTI KATIYAR, Dr. PANKAJ MISHRA, & JEEVAN CHANDRA PANDEY (May-2022). FORMULATION AND CHARACTERIZATION OF EUDRAGIT RS 100 NANOSUSPENSION FOR OCULAR DELIVERY OF INDOMETHACIN . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(5), 1340-1352. https://ijnrd.org/papers/IJNRD2205180.pdf

Volume 7 Issue 5, May-2022

Pages : 1340-1352

Paper Reg. ID: IJNRD_181592

Published Paper Id: IJNRD2205180

Research Area: Pharmacy

Author Type: Indian Author

Country: Bareilly, UTTAR PRADESH, India

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