|
|||||||||||||||
|
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
||||||||||||||
Issue: April 2024
Volume 9 | Issue 4
Review Result and Publication of Paper within : 2-3 days
Click Here For more DetailsFor Authors
Forms / Download
Published Issue Details
Editorial Board
Other IMP Links
Facts & Figure
Impact Factor : 8.76
Issue per Year : 12
Volume Published : 9
Issue Published : 95
Article Submitted :
Article Published :
Total Authors :
Total Reviewer :
Total Countries :
Indexing Partner
Join RMS/Earn 300
Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
Published Paper Details
|
|
| Paper Title: | ANALYTICAL METHOD VALIDATION OF METFORMIN HCL AND LINAGLIPTIN TABLET BY HPLC |
| Authors Name: | Prakash Neupane , Sunita Arya , Gulbahar , Pratishma pandey |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_182429
|
| Published Paper Id: | IJNRD2208058 |
| Published In: | Volume 7 Issue 8, August-2022 |
| DOI: | |
| Abstract: | An accurate, precise, economical, reproducible high-performance liquid Chromatographic method has been developed for the quantitative estimation of Metformin hydrochloride and Linagliptin simultaneously in the tablet dosage form. The instruments consisted of Agilent model G1310B 1260 infinity Iso pump equipped with a UV detector and Agilent model 1260 infinity autosampler equipped with a UV detector. The separation was carried out using Agilent column C18 150 cm 25 cm x 4.6 mm packed with Octadecylsilane bonded to porous silica (5µm) with a flow rate of 1.0 ml/min, column temperature ambient, and UV detector set at 265 and 295 nm. The mobile phase is comprised of phosphate Buffer 0.02M (2.7216 g Potassium Dihydrogen Orthophosphate dissolved in 1000 ml of water and, Acetonitrile in the ratio of 70:30 (v/v). The method was selective for Metformin HCL and Linagliptin with retention times 0.954 min and 2.226 min, respectively. The linearity was established over the 4000-6000 mcg/ml concentration range and 20-30 mcg/ml for Metformin HCL and Linagliptin, respectively. The developed method was validated by ICH harmonized tripartite guidelines: “Validation of analytical procedures: text and methodology Q2(R1)”. The statistical result showed that the method was precise, accurate, reproducible and specific for the analysis of Metformin HCL and Linagliptin. The marketed sample of Metformin HCL and Linagliptin combination immediate release tablet dosage form was analysed by the developed method. The proposed method is suitable for routine quality control analysis of Metformin Hydrochloride and Linagliptin in a Tablet dosage form. |
| Keywords: | |
| Cite Article: | "ANALYTICAL METHOD VALIDATION OF METFORMIN HCL AND LINAGLIPTIN TABLET BY HPLC", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 8, page no.516-524, August-2022, Available :http://www.ijnrd.org/papers/IJNRD2208058.pdf |
| Downloads: | 000118757 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID:IJNRD2208058 Registration ID: 182429 Published In: Volume 7 Issue 8, August-2022 DOI (Digital Object Identifier): Page No: 516-524 Country: Dehardun, Uttarakhand, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2208058 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2208058 |
| Share Article: |
|
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijnrd.org
| Semantic Scholar | Microsaoft Academic | ORCID | Zenodo |
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | PUBLON |
| DRJI | SSRN | Scribd | DocStoc |
ISSN Details
 |
 |
|
ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
DOI (A digital object identifier)
Conference
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Important Details
Social Media
Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Join RMS/Earn 300
| Copyright © 2024 - All Rights Reserved - IJNRD |
Facebook Twitter Instagram LinkedIn