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IJNRD
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

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Paper Title: METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF MEMANTINE AND DONEPEZIL IN MARKETED FORMULATION USING HYDROTROPY PHENOMENA
Authors Name: SHUBHANSHI SAXENA , SARITA KAROLE , KAVITA R LOKSH , ANUP CHKARBORTY , UDIT N. SONI
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IJNRD_183928
Published Paper Id: IJNRD2211118
Published In: Volume 7 Issue 11, November-2022
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Abstract: "Hydrotropy" has been used to designate the increase in solubility of various substances due to the presence of large amounts of additives. Various hydrotropic agents such as sodium salicylate, sodium benzoate, urea, nicotinamide, sodium citrate and sodium acetate have been used to enhance the aqueous solubility of a large number of drugs. The hydrotropes are a special class of compounds that exhibit distinct solution properties. They may self-associate in aqueous medium, comparable to amphiphile self-association or micellization. They are efficient solubilizers and can influence the formation of micelle and micro emulsion. Using hydrotropic agents is one of the easiest ways of increasing water solubility of poorly soluble drugs, since it only requires mixing the drugs with the hydrotrope in water. The hydrotrope approach does not require chemical modification of hydrophobic drugs, use of organic solvents, or preparation of emulsion systems. Considerable research has focused on attaching drugs to polymers in order to improve pharmacokinetic properties.
Keywords: Hydrotropy, Aqueous solubility, amphiphile, micellization, solubilizers, micro emulsion, pharmacokinetic properties
Cite Article: "METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF MEMANTINE AND DONEPEZIL IN MARKETED FORMULATION USING HYDROTROPY PHENOMENA", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 11, page no.b177-b186, November-2022, Available :http://www.ijnrd.org/papers/IJNRD2211118.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2211118
Registration ID: 183928
Published In: Volume 7 Issue 11, November-2022
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Page No: b177-b186
Country: Bhopal, Madhyapradesh, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2211118
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2211118
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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