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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Rationalizing Biological Pathways Responsible In Metastatic Triple Negative Breast Cancer via Identification and Validation of Hub Genes |
| Authors Name: | Architha Sankar |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_184386
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| Published Paper Id: | IJNRD2211266 |
| Published In: | Volume 7 Issue 11, November-2022 |
| DOI: | http://doi.one/10.1729/Journal.32288 |
| Abstract: | Triple Negative Breast Cancer (TNBC) is a severe form of breast cancer with an increased incidence of metastasis and relapse. Since, the current conventional method of treatment remains ineffective due to poor diagnosis and lack of therapeutic targets, it remains an unsettling challenge for both researchers and clinicians in the field. The centerpiece of our study was to unwind the Differentially Expressed Genes (DEGs), its pathway enrichment analysis underlying the metastatic condition of the disease. We had chosen multiple datasets from distant metastasis and metastatic TNBC stages for investigation. From these disease-specific expression network analysis, ten hub genes namely: SMC4, BUB1B, CCNA2, KIF2C, KIF15, PBK, CDCA5, CENPE, ZWINT and MELK were identified and validated by survival and correlation analysis. In our attempt to highlight the biological pathway that our hub genes were majorly involved, further analysis revealed that cleavage of centromeric cohesion by ESPL1 (Separase) in mitotic cell cycle were found to be enriched which demonstrates that these hub genes are responsible in triggering tumor invasion and metastasis. Concisely, our report will aid in gaining a better understanding of biological complexities, revealing potential biomarkers and therapeutic targets implicated in metastasis of TNBC. |
| Keywords: | Hub Genes, Triple-Negative Breast Cancer, In-silico Analysis, DEG’s, Metastasis. |
| Cite Article: | "Rationalizing Biological Pathways Responsible In Metastatic Triple Negative Breast Cancer via Identification and Validation of Hub Genes", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 11, page no.c543-c554, November-2022, Available :http://www.ijnrd.org/papers/IJNRD2211266.pdf |
| Downloads: | 000118806 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2211266 Registration ID: 184386 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.32288 Page No: c543-c554 Country: Chennai, Tamil Nadu, India Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2211266 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2211266 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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