INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Diferuloylmethane is a major component of rhizomes of Curcuma longa and has array of pharmacological activities. Poor bioavailability of the molecule is due to its poor solubility in water. In the present study, an attempt is made to increase the water solubility through preparation of Rock Hard Dissemination (RHD) of Diferuloylmethane and Gelucire®44/14, followed by incorporation of the same in Algiline Nonsubmersible Chaplet (ANSC). The formation of RHD was confirmed through FT-IR and DSC –TG analysis. The maximum entrapment of Diferuloylmethane in the chaplet was found to be 30 % w/w. The dissolution studies of the chaplet in 0.1N HCl, revealed that the Diferuloylmethane release from the chaplet containing RHD is significantly (p<0.001) higher than the chaplet containing plain Diferuloylmethane. Pharmacokinetic studies on chaplet containing RHD of Diferuloylmethane indicated significantly (P< 0.001) higher levels of Diferuloylmethane serum as compared to the plain Diferuloylmethane.
Keywords:
Diferuloylmethane, Rock hard dissemination, Algiline, Diferuloylmethane Nonsubmersible chaplet, Bioavailability, Gelucire@44/14.
Cite Article:
"ALGILINE DIFERULOYLMETHANE NONSUBMERSIBLE CHAPLET CONTAINING DIFERULOYLMETHANE ROCK-HARD DISSEMINATION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b209-b222, December-2022, Available :http://www.ijnrd.org/papers/IJNRD2212120.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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