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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | DESIGN DEVELOPMENT AND FORMULATION OF CONTROLLED RELEASED MICROSPHERE OF ANTI-DIABETIC DRUG |
| Authors Name: | Mr. Ajit Das , Dr. C.K. Tyagi |
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IJNRD_185027
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| Published Paper Id: | IJNRD2212183 |
| Published In: | Volume 7 Issue 12, December-2022 |
| DOI: | |
| Abstract: | The objective of the present study was to develop Gliclazide microspheres in order to achieve an extended retention in the upper GIT. Which may result in enhance the absorption and improve the bioavailability. The microspheres were prepared by emulsion solvent diffusion-evaporation method using different ratios of rate controlling polymer poloxamer 407, Gliclazide is used in each formulation at constant ratio. The mixture of dichloromethane and ethanol at ratio of (1:1), with tween 80 as the surfactant. The prepared microspheres were evaluated for percentage yield, particle size, entrapment efficiency, shape and surface characterization, in vitro dissolution studies and drug release mechanism was interpretated by kinetic model. The effect of polymer concentration on these parameters was investigated. The studies revealed that increase in concentration of hydrophilic non-ionic polymer (Poloxamer 407) increased the drug release from the microspheres. The formulation F6 (Gliclazide: poloxamer 407 is 1:6) was selected as best formulation, and it follows zero order drug release with 89.36% entrapment efficiency, 98.16% drug content, 93.85% In-vitro drug release at 12thhour. |
| Keywords: | DESIGN DEVELOPMENT AND FORMULATION OF CONTROLLED RELEASED MICROSPHERE OF ANTI-DIABETIC DRUG |
| Cite Article: | "DESIGN DEVELOPMENT AND FORMULATION OF CONTROLLED RELEASED MICROSPHERE OF ANTI-DIABETIC DRUG", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b727-b739, December-2022, Available :http://www.ijnrd.org/papers/IJNRD2212183.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2212183 Registration ID: 185027 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: b727-b739 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2212183 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2212183 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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