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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Carbonic Anhydrase Inhibitors: Docking, Synthesis and Evaluation of Sulfonamide bearing Amino-Acid as CAII Inhibitors |
| Authors Name: | Mrs. Darshana Shrivastava , Dr. Meena Tiwari , Diksha Gawshinde |
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IJNRD_186310
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| Published Paper Id: | IJNRD2301231 |
| Published In: | Volume 8 Issue 1, January-2023 |
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| Abstract: | Abstract A set of twelve of p-amino benzene sulfonamides derivatives containing amino acids were synthesized. The synthesized compounds were characterized and tested for their bCA II inhibitory activity, taking acetazolamide as standard. The percentage of bCAII inhibitory activity of the synthesized compounds ranged from 20-78 at a concentration of 0.1*103µm. The highest inhibition was shown by compound D2 (78.53) which is comparable to acetazolamide (78.62). The lowest inhibition was shown by compound D9 (20.02) respectively. Docking analysis of the synthesized compounds was also performed using GOLD software. The PDB ID 4HT0 was selected for docking studies. All the synthesized compounds show same interaction of nitrogen (N1 and N2) atoms with Zn2+, Oxygen atom of SO2 forms H- bonding with Thr forming tetrahedral geometry. The distance between the nitrogen (N1and N2) atoms and Zn2+ in the synthesized compounds is similar to that of distance between the nitrogen (N1andN2) atoms and Zn2+ found in standard drug acetazolamide. |
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| Cite Article: | "Carbonic Anhydrase Inhibitors: Docking, Synthesis and Evaluation of Sulfonamide bearing Amino-Acid as CAII Inhibitors", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 1, page no.c224-c232, January-2023, Available :http://www.ijnrd.org/papers/IJNRD2301231.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2301231 Registration ID: 186310 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: c224-c232 Country: Bhopal, madhya pradesh, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2301231 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2301231 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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