INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
ABSTRACT
Acute Promyelocytic Leukaemia (APML) is characterized by a block in differentiation where Leukemic cells are halted at the promyelocyte stage. A characteristic balance chromosomal Translocation between chromosomes 15 and17 t (15;17) is seen in 95% of cases – the translocation results in the formation of the PML-RARA fusion protein the introduction of retinoic acid (RA) and Arsenic trioxide (ATO) has been responsible for initially remar-kable cure rates. Acute promyelocytic leukaemia is a distinct subtype of acute myeloid leukaemia. The disease is characterized by a chromosomal abnormality involving translocation between chromosomes 15 and 17. Current therapy has advanced to include agents such as all-trans retinoic acid and arsenic trioxide, which have improved remission and survival rates. Induction, consolidation, and maintenance regimens have now been studied and are outlined. As patients affected can develop severe bleeding complications, rapid diagnosis and initiation of appropriate treatment are vital. During treatment, unique complications such as disseminated intravascular coagulation and differentiation syndrome can occur. Prompt recognition of complications is imperative.
Keywords:
APML
Cite Article:
"Acute Promyelocytic Leukemia (APML)", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 1, page no.c525-c528, January-2023, Available :http://www.ijnrd.org/papers/IJNRD2301272.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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