Paper Title
Autophagy
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Registration ID: IJNRD_187155
Published ID: IJNRD2302093
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Keywords
ATG proteins, autophagic lysosome reformation, autophagy, apoptosis, stress, mechanisms, energy, disease, cancer, neurodegeneration, infection
Abstract
Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform to allow degradation of intracellular components, including soluble proteins, aggregated proteins, organelles, macromolecular complexes, and foreign bodies. Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy can be either non-selective or selective in the removal of specific organelles, ribosomes and protein aggregates, although the mechanisms regulating aspects of selective autophagy are not fully worked out. In addition to elimination of intracellular aggregates and damaged organelles, autophagy promotes cellular senescence and cell surface antigen presentation, protects against genome instability and prevents necrosis, giving it a key role in preventing diseases such as cancer, neurodegeneration, cardiomyopathy, diabetes, liver disease, autoimmune diseases and infections. This review summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease.
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How To Cite (APA)
Ms.sonali Balasaheb Jadhav , Dr.Kambale H.V., & Prof.Waghmare.S.A. (February-2023). Autophagy . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), a929-a937. https://ijnrd.org/papers/IJNRD2302093.pdf
Issue
Volume 8 Issue 2, February-2023
Pages : a929-a937
Other Publication Details
Paper Reg. ID: IJNRD_187155
Published Paper Id: IJNRD2302093
Research Area: Pharmacy
Author Type: Indian Author
Country: Ahmednagar , Maharashtra , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2302093.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302093
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