Development and optimization of orodispersible films for the treatment of mouth ulcer

Manjunatha , Beny Baby , S. Rajarajan , Rashmi mathews , K Ramesh

Orodispersible dosage forms are new methods for drug delivery system. Orodispersible dosage forms are the most advanced form of oral solid dosage form Because of their more flexibility and convenience. It enhances the efficacy of APIs by dissolving in the oral cavity within a minute without the need for water. The aim of the study was to develop an orodispersible film (ODF) as an alternative dosage forms as compared to tablets, syrups, or suppositories. This is mainly focused on the treatment of mouth ulcers, especially for the peadiatric and geriatric patients. The Solvent Casting method was used to prepare orodispersible films of dexlansoprazole by incorporating polymers such as HPMC, Lycoat RS780, Croscarmelallose as disintegrates, and PEG 400 as plasticizers. The orodispersible films of dexlansoprazole were evaluated to weight variation, Drug content, surface pH, Disintegration time, Swelling Index, Folding Endurance, Film Thickness and In-vitro drug release. The drug release tests were carried out for 8 hours at 37°C1°C in phosphate buffer (pH 6.8). The optimised formulation was carried out with the help of a design expert in the Quadratic model 13.0.5.0 version. The optimised formulation of orodispersible films was subjected to an accelerated stability study and found to be stable at 40°C/75% RH for 3 month according to ICH guidelines. The results, results of the orodispersible films of dexlansoprazole, evaluation of all physicochemical parameters will reveal good results. The orodispersible films of dexlansoprazole for the drug release study at 8h, % cumulative drug release of 83.90 to 96.80%. The optimised formulation for design was found to be DL15, which showed 86.90% drug release at 8h and DL15 was found to be stable when stored at 40ºC/75% RH for 3 month according to ICH guidelines with no significant changes on further stability study.

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"Development and optimization of orodispersible films for the treatment of mouth ulcer", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.a143-a156, March-2023, Available :https://ijnrd.org/papers/IJNRD2303014.pdf

Volume 8 Issue 3, March-2023

Pages : a143-a156

Paper Reg. ID: IJNRD_186647

Published Paper Id: IJNRD2303014

Downloads: 000118868

Research Area: Pharmacy

Country: Bangalore , Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303014

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303014

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

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