In-Vivo Anti-Arthritic Effect Of Combination Of Boswellic Acid, Berberine And Silymarin In Freund's Complete Adjuvant Induced Arthritis In Rats

Shrikanta , Bhargav A , Dr. Rama Nargund , Wani Adil Rashid

Boswellic acid, berberine, silymarin and Freund’s complete adjuvant

Rheumatoid arthritis is a chronic autoimmune disease, which affects approximately 1% adult population. Boswellic acid, berberine, silymarin are major constituent of boswellia serrata, berberies aristata and milk thistle respectively and are reported to be effective as anti-inflammatory and anti-arthritic activity. The present study was undertaken to evaluate anti-arthritic activity of combination of boswellic acid, berberine, silymarin in FCA-induced arthritic rats. BBS (150 mg/kg bw p.o) was administered for 28 days and various physical (body weight, paw volume and paw thickness), haematological, biochemical and histopathological parameters were assessed. The BBS showed a significant (P<0.001) reduction in paw volume and paw thickness from the 14th to 28th day in the developing phase and reversed the haematological and biochemical parameters as compared to arthritic rats. Histological reports also suggested that histological changes reversed in BBS treated rats. BBS treatment in developed phase has shown moderate anti-arthritic effect. Present study indicated that BBS formulation has significant anti-arthritic activity and beneficial in early stage of arthritis and moderate effect in late stages. Further studies are needed to explore the underlying mechanism in molecular level.

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"In-Vivo Anti-Arthritic Effect Of Combination Of Boswellic Acid, Berberine And Silymarin In Freund's Complete Adjuvant Induced Arthritis In Rats", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.a585-a592, March-2023, Available :https://ijnrd.org/papers/IJNRD2303059.pdf

Volume 8 Issue 3, March-2023

Pages : a585-a592

Paper Reg. ID: IJNRD_188346

Published Paper Id: IJNRD2303059

Downloads: 000118906

Research Area: Pharmacy

Country: Udupi, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303059

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303059

DOI: http://doi.one/10.1729/Journal.34589

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

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