BUCCAL DRUG DELIVERY SYSTEM: THE CURRENT APPROACHES
Mr.Sanjay Shahurao Popale
, Dr. Pankaj Motilal Chaudhari , Mrs Smita Pandharinath Wasnik
Mucoadhesive buccal patch, Natural polymer, Bioadhesive polymers, Buccal formulations, Buccal Mucosa, first-pass effect, permeation enhancers.
Since the early 1980s there has been renewed interest in the use of bioadhesive polymers to prolong contact time in the various mucosal routes of drug administration. As we all know that, the buccal cavity is highly acceptable by patients, the mucosa is relatively permeable with a rich blood supply. Bypass of the gastrointestinal tract and hepatic portal system, increasing the bioavailability of orally administered drugs that otherwise undergo hepatic firstmetabolism.
The buccal region of the oral cavity is an attractive target for administration of the drug of choice, particularly in overcoming deficiencies associated with the latter mode of administration. Problems such as high first-pass metabolism and drug degradation in the gastrointestinal environment can be circumvented by administering the drug via the buccal route. Moreover, rapid onset of action can be achieved relative to the oral route and the formulation can be removed if therapy is required to be discontinued. It is also possible to administer drugs to patients who unconscious and less co- operative. To prevent accidental swallowing of drugs adhesive mucosaldosage forms were suggested for oral delivery, which included adhesive tablets, adhesive gels, adhesive patches and many other dosage forms with various combinations of polymers, absorption enhancers. Natural polymers have recently gained importance in pharmaceutical field. Mucoadhesive polymers are used to improve drug delivery by enhancing the dosage form‟s contact time and residence time with the mucous membranes. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. When the biological substrate is attached to a mucosal layer then this phenomenon is known as mucoadhesion. The substrate possessing bioadhesive polymer can help in drug delivery for a prolonged period of time at a specific delivery site. The studies of Mucoadhesive polymers provide a good approach of mucoadhesion and some factors which have the ability to affect the mucoadhesive properties of a polymer. Both natural and synthetic polymers are used for the preparation of mucoadhesive buccal patches. In addition to this, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity.. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety ofdrugs.
"BUCCAL DRUG DELIVERY SYSTEM: THE CURRENT APPROACHES", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.a672-a683, March-2023, Available :https://ijnrd.org/papers/IJNRD2303069.pdf
Volume 8
Issue 3,
March-2023
Pages : a672-a683
Paper Reg. ID: IJNRD_188358
Published Paper Id: IJNRD2303069
Downloads: 000118877
Research Area: Pharmacy
Country: Ahmednagar , Maharashtra , India
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave
