Synthesis and Evaluation of Antimicrobial and Anti-inflammatory Activity of Oxadiazole Derivatives

RAM BABAN INGLE , MISS.K.A. DALAVI

Anti-inflammatory, Antimicrobial and Oxadiazole.

The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. In the present proposal, aromatic aldehyde was made to react with ethyl acetoacetate in presence of ammonia to yield 1, 4-dihydropyridine derivatives. 1, 4-dihydropyridine was refluxed in presence of hydrazine and ammonia to yield offer corresponding hydrazides. Hydrazide was refluxed with an aromatic acid along with addition of phosphorous to offer final compounds. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 µcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E. coli, S. aureus, A. niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard. These compounds with the suitable molecular modification may prove as a drug of choice in the treatment of microbial infectious disease in future.

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"Synthesis and Evaluation of Antimicrobial and Anti-inflammatory Activity of Oxadiazole Derivatives", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.c130-c141, March-2023, Available :https://ijnrd.org/papers/IJNRD2303219.pdf

Volume 8 Issue 3, March-2023

Pages : c130-c141

Paper Reg. ID: IJNRD_188778

Published Paper Id: IJNRD2303219

Downloads: 000118858

Research Area: Chemistry

Country: buldhana, maharastra, india

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303219

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303219

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

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