FORMULATION AND EVALUATION OF CANDY DOSAGE FORM OF ALBENDAZOLE FOR PAEDIATRICS

Ananda Lamsal , Bijaya Laxmi Giri , Hari Datta Subedi, , Upendra Kumar Yadav , Binita Sunar

FORMULATION AND EVALUATION OF CANDY DOSAGE FORM OF ALBENDAZOLE FOR PAEDIATRICS

Candy are flavored medicated dosage form intended to be sucking and held in the mouth or pharynx containing one or more medicaments usually in the sweetened base. Medicated candy is designed to improve patient compliance, acceptability. Albendazole is a broad-spectrum anthelmintic. It is widely used for the management and treatment of intestinal nematode infection. This project concluded the possibility of developing Albendazole Candy by heating and congealing method using methylcellulose, citric acid as polymer. The dissolution was carried out in USP II paddle type dissolution apparatus. The Physiochemical properties like general appearance of albendazole, preformulation evaluation i.e tapped density, bulk density, Hausner’s ratio, angle of repose and solubility and post formulation evaluation i.e weight variation, drug content uniformity and drug dissolution were evaluated of different batches or formulation from F1 to F9 which complies the specifications. The drug release was best fitted to model depended zero order release kinetics and Formulation 5 is the better formulation among all. Also using similarity and dissimilarity factor, from the obtained results it is clear that the drug release from the nine formulations are highly similar.

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" FORMULATION AND EVALUATION OF CANDY DOSAGE FORM OF ALBENDAZOLE FOR PAEDIATRICS", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.c578-c593, March-2023, Available :https://ijnrd.org/papers/IJNRD2303268.pdf

Volume 8 Issue 3, March-2023

Pages : c578-c593

Paper Reg. ID: IJNRD_188886

Published Paper Id: IJNRD2303268

Downloads: 000118928

Research Area: Engineering

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Published Paper PDF: https://ijnrd.org/papers/IJNRD2303268

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303268

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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