Azadirachta Indica (Neem) a Potential Alternative for the Treatment of Acne: A Systematic Review of Randomized Controlled Trial

Shubham Sharma , Khushboo Kumari , Hitesh Gupta , Rabindra Ku. Sah

Keywords: Acne, azadirachta indica, randomized control trial, review

Introduction: Modern science has improved mankind's life expectancy, but is often limited to better off of society. Acne is a physiologically harmful skin condition that primarily affects adolescents and has negative side effects from contemporary treatment. Neem an age-old traditional tree from India used to treat skin ailments, lacks contemporary evidence in the treatment of acne. Hence, we aimed to sieve the efficacy and safety of neem in acne in a systematic manner. Methods: This review systematically searched for randomized control trials in four databases in the last ten years to determine the efficacy and safety of neem in acne treatment. Data from these trials are presented in two MS Excel grids, and the methodology of each study is assessed. Results: Twenty-five full-text articles were screened of which only two articles got included following inclusion criteria. The two single-blind, randomized clinical trials were conducted in India, having a study duration of 6 weeks, with a total of 121 acne patients. Azadirachta indica (neem) application reported a positive efficacy in the subjective and objective outcome, along with non-serious adverse events. Conclusion: Neem safety and effectiveness in acne is difficult to be generalized due to limited trials, hence both clinicians and patients should be cautious. Double-blind, enhanced duration, and with a higher sample size trial is suggested. PROSPERO Registration: CRD42022359779

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"Azadirachta Indica (Neem) a Potential Alternative for the Treatment of Acne: A Systematic Review of Randomized Controlled Trial", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.d111-d126, March-2023, Available :https://ijnrd.org/papers/IJNRD2303318.pdf

Volume 8 Issue 3, March-2023

Pages : d111-d126

Paper Reg. ID: IJNRD_189265

Published Paper Id: IJNRD2303318

Downloads: 000118855

Research Area: Pharmacy

Country: DURG, CHHATTISGARH, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303318

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303318

DOI: http://doi.one/10.1729/Journal.33414

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition