The Vesicular Transfersome: An Permeation Enhancer Carrier of Low Permeability Drug

Mr. Vaibhavkumar Bapu Bhagwat , Mr. Kharade Rajendra Gulab , Mr. Survase Abhijeet B. , Mr. Ban Amol Ankush

Transfersomes, Deformable and Ultra Vesicles, Transdermal Route, Edge Activators, Phosphatidylcholine, Stratum Corneum.

The aim of the research was to develop the Transfersomes, a novel vesicular carrier for the better activities of anti-inflammatory by reducing the gastro intestinal toxicity which associated with oral administration. Drug including Transfersomes prepared by Thin Film Hydration Techniques using surfactants is an edge activator, phospholipids and drug use in different ratios. The prepared Transfersomes were evaluated for the particle size, entrapment efficiency, zeta potential, in vitro drug release, and transmission electron microscopy. The drug and Excipients compatibility were done by using Fourier transform infrared spectroscopy [FT-IR] and found compatible with each other. The optimized batch Transfersomes were exhibit vesicle size. The optimized batch formulations of Transfersomes were incorporated in polymer and evaluated in comparison with marketed product for drug content, pH, spreadability, in vitro permeation. The deformed vesicle formed formulation exhibit better performance in combination with edge activator rather than branded formulation. Based upon the analyzed parameters such as drug release it can be concluded that transfersome formulation containing Drug provides better permeation rate in comparison to the marketed one.

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"The Vesicular Transfersome: An Permeation Enhancer Carrier of Low Permeability Drug", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 3, page no.d753-d759, March-2023, Available :https://ijnrd.org/papers/IJNRD2303397.pdf

Volume 8 Issue 3, March-2023

Pages : d753-d759

Paper Reg. ID: IJNRD_189610

Published Paper Id: IJNRD2303397

Downloads: 000118833

Research Area: Pharmacy

Country: Dist-Pune, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303397

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303397

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition