INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
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Published Paper Details
Paper Title:
Development and Validation of LC-MS/MS method for simultaneous estimation of Metronidazole and Rifaximin in Pharmaceutical dosage form and Characterize degradants
Authors Name:
Jignesh Chauhan
, Mr.Nachiketa Pandya , Dr. Chaitanya Bhatt
A simple, rapid, precise and accurate Stability indicating LC-MS/MS method for simulta-neous estimation of Metronidazole and Rifaximin in their combined dosage form has been developed. The separation was achieved by Agilent, Zorbax, C18, (150mm x 4.6mm), 5µm column and Buffer (Ammonium formate, pH4.0): Acetonitrile (75:25) as mobile phase, at a flow rate of 1 ml/min. Detection was carried out. Retention time of Rifaximin and Metroni-dazole were found to be 4.9 min and 2.6 min respectively. The method has been validated for linearity, accuracy and precision. Linearity observed for Metronidazole 2-6μg/ml and for Rifaximin 1-3 μg/ml. Developed method was found to be accurate, precise and rapid for simultaneous estimation of Metronidazole and Rifaximin their Combined Dosage Form. The drug was subjected to stress condition of hydrolysis, oxidation, photolysis and Thermal degradation, Considerable Degradation was found in Alkali and Oxidation degradation. The proposed method was successfully applied for the simultaneous estimation of both the drugs in commercial combined dosage form.
"Development and Validation of LC-MS/MS method for simultaneous estimation of Metronidazole and Rifaximin in Pharmaceutical dosage form and Characterize degradants", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.c67-c83, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305211.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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