Clinical overview of Deferasirox Ion Chelation Theropy

Registration ID: IJNRD_194499

Published ID: IJNRD2305243

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Divya Diliprao Deshmukh, Aarti Nivas Patil, Rushikesh Janik Divate

Deferasirox, iron overload, thalassemia, sickle cell disease, and myelodysplastic syndrome are some of the terms that may be used.

Deferasirox, an oral iron chelator that is given once daily, is often used in the treatment of people with transfusional hemosiderosis. In several Phase II trials and their respective extension studies, as well as a Phase III trial, the effectiveness and safety of this novel agent in transfusion-dependent patients with -thalassemia, sickle cell disease, and bone marrow failure syndromes, including myelodysplastic syndrome and aplastic anemia, have been established. According to evidence from several clinical trials, a deferasirox dose of 20 mg/kg/day stabilises serum ferritin levels and liver iron concentration, while a dose of 30-40 mg/kg/day reduces these values and causes negative iron balance in red cell transfusion-dependent patients with iron overload. In multiple important clinical trials, deferasirox was well tolerated, with the most common side effects being gastrointestinal issues, skin rashes, non-progressive blood creatinine rises, and elevations in liver enzyme levels. Longer-term extension studies have also demonstrated the efficacy and safety of deferasirox. Patients taking deferasirox therapy must be routinely observed to ensure quick treatment for any side effects that may develop with long-term medication.

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Divya Diliprao Deshmukh, Aarti Nivas Patil, & Rushikesh Janik Divate (May-2023). Clinical overview of Deferasirox Ion Chelation Theropy. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), c316-c325. https://ijnrd.org/papers/IJNRD2305243.pdf

Volume 8 Issue 5, May-2023

Pages : c316-c325

Paper Reg. ID: IJNRD_194499

Published Paper Id: IJNRD2305243

Research Area: Pharmacy

Author Type: Indian Author

Country: Jalna, Maharashtra, India

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