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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Formulation development and evaluation of nanoparticles of Anti-diabetic drug by Hot Homogenization technique |
| Authors Name: | Mr. Shubham S. Ingavale , Mr. Sumit S. Chavan , Mr. Vaibhav L. Kharat , Mr. Tushar D. Bhosale , Prof. Vikas B. Wamane |
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IJNRD_195820
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| Published Paper Id: | IJNRD2305486 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | Nanostructured lipid carriers of glimepiride (NLC) have been developed for the treatment of type 2 diabetes. The developed NLC consists of Compritol ATO 888 as a solid lipid, medium chain triglycerides as a liquid lipid, and Poloxamer 188 as a surfactant. NLCs were prepared using a hot homogenization method and characterized by FT-IR. All NLCs showed recording efficiency in the range of 78.52 to 90.38%. Both the capture efficiency and the release rate were affected by the lipid concentration. Formulation F5 was considered an optimized formulation based on particle size and percentage of drug release. The zeta potential value indicated good stability of the particles. The optimized formulation showed no physical/chemical changes when exposed to accelerated stability conditions. It was concluded that the developed NLC is a potential approach for controlled medication that can reduce dosing frequency and improve patient compliance. |
| Keywords: | Glimepiride, hot homogenization technique, Nanocapsule, nanopartical, homogenization |
| Cite Article: | "Formulation development and evaluation of nanoparticles of Anti-diabetic drug by Hot Homogenization technique", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.e694-e709, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305486.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2305486 Registration ID: 195820 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: e694-e709 Country: Shrirampur, maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305486 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305486 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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