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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFEN USING TAMARIND KERNAL POWDER AS MUCO ADHESIVE POLYMER |
| Authors Name: | SAILAJA RONGALI , Jagadeesh panda , G.Kusuma , V.Keerthana G. Rohini , V.Geethika sai |
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IJNRD_196861
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| Published Paper Id: | IJNRD2305769 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | AIM: The aim of the work is to formulate and evaluate the transdermal patches of ketoprofen using different combinations of polymers and plasticizers. OBJECTIVE: •. Transdermal patches of ketoprofen were prepared to sustain the release and patient compliance. Different formulations were prepared by using different combinations of the polymers like HPMC E5 LV: Eudragit E 100. (1:1,1:2,1:3) and Ethyl cellulose and PVP ratio (1:1,1:2,1:3)by solvent casting method. Tamarind kernel powder is used as a mucoadhesive polymer. The prepared formulations were evaluated for various parameters like moisture content, moisture uptake, folding endurance , percentage drug content , In-vitro permeation using Franz diffusion cell, drug-excipient compatibility by FTIR studies. The diffusion data was fitted into various kinetic models (zero order, first order, Higuchi and Korsmeyer peppas model). The formulation containing the combination of Ethyl cellulose and PVP at a ratio of 1:3 using PEG 4000 as plasticiser was considered optimum batch and showed the drug release up to 8hrs ,91.78% and more similar to the marketed ketoprofen patch (30mg) and similarity factor was calculated as f2=60.78. |
| Keywords: | Tansdermal patch, ketoprofen, Ethyl cellulose, tamarind kernel powder, Franz Diffusion cell and controlled release |
| Cite Article: | "FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFEN USING TAMARIND KERNAL POWDER AS MUCO ADHESIVE POLYMER", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.h510-h517, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305769.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2305769 Registration ID: 196861 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: h510-h517 Country: visakhapatnam, Andhra Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305769 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305769 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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