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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Clinical translation potential from animal to human in Alzheimer's Disease |
| Authors Name: | Eshani Mahajan |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_197549
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| Published Paper Id: | IJNRD2305849 |
| Published In: | Volume 8 Issue 5, June-2023 |
| DOI: | |
| Abstract: | Alzheimer's disease (AD) is a chronic, progressive, and neurodegenerative disorder. Five drugs approved by FDA to treat Alzheimer's disease. The first four are Donepezil, Memantine, Rivastigmine, and Galantamine. The fifth one is a fixed dose combination of Memantine as well as Donepezil. All these drugs treat Alzheimer's only symptomatically. So, there is an urgent need to investigate a drug that can provide both symptomatic as well as curative treatment for Alzheimer's. Huge experimental research is going on but still, there is a lack of translation potential of experimental data into clinics. Various factors are responsible for this which include lack of efficacy, severe adverse effects, complex genetics, difficulty in the recruitment process of AD clinical trials, lack of understanding of the disease pathology, or complex pathophysiology of the disease. There are various ways to address these challenges in dementia research which include increasing the funding for dementia research, increase in public awareness of AD and other dementia, incorporating dementia research into the care continuum, improving access to clinical trials, and decreasing risks of the drug development process of AD. Therefore, in this review, preclinical limitations which hamper the drug development process for the treatment of Alzheimer's disease are summarized. |
| Keywords: | Keywords: Alzheimer's disease, Amyloid beta, Acetylcholinesterase inhibitors, preclinical studies, clinical trials, pathophysiology |
| Cite Article: | "Clinical translation potential from animal to human in Alzheimer's Disease", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.i369-i393, June-2023, Available :http://www.ijnrd.org/papers/IJNRD2305849.pdf |
| Downloads: | 000118755 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID:IJNRD2305849 Registration ID: 197549 Published In: Volume 8 Issue 5, June-2023 DOI (Digital Object Identifier): Page No: i369-i393 Country: Chandigarh , Chandigarh , India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305849 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305849 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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