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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Formulation Design and Optimization of Fast Disintegrating Tablets of Atorvastatin Calcium Using Solid Dispersion Technique |
| Authors Name: | Mr. Manish Kumar Chaudhary , Mr. Kashif Hussain , Dr. Yogita Tyagi , Mr. Praveen Kumar Ashok |
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IJNRD_199292
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| Published Paper Id: | IJNRD2306376 |
| Published In: | Volume 8 Issue 6, June-2023 |
| DOI: | |
| Abstract: | The purpose of the present investigation was to increase the solubility and dissolution rate of atorvastatin calcium by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 (PVP K30) using kneading method. Drug polymer interactions were investigated using differential scanning calorimetry (DSC), x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). For the preparation of atorvastatin calcium fast disintegrating tablets, its 1:6 solid dispersion with PVP K30 was used with various natural and synthetic superdisintegrants. In an attempt to construct a statistical model for the prediction of wetting time, disintegration time and percentage dissolution, a 32 full factorial design was used to optimize the influence of the amounts of superdisintegrants. The obtained results showed that dispersion of the drug in the polymer considerably enhanced the dissolution rate. The drug-to-carrier ratio was the controlling factor for dissolution improvement. FTIR spectra revealed no chemical incompatibility between the drug and PVP K30. As indicated from XRD and DSC data, atorvastatin calcium was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispersions. Concerning the optimization study, the regression analysis revealed that an optimum concentration of SSG and crospovidone are required for obtaining fast disintegrating tablets. In conclusion, this investigation demonstrated the potential of experimental design in understanding the effect of the formulation variables on the quality of fast disintegrating tablets containing solid dispersion of a hydrophobic drug. |
| Keywords: | Atorvastatin calcium, polyvinyl pyrrolidone K30, solid dispersion, kneading method, fast disintegrating tablets, factorial design |
| Cite Article: | "Formulation Design and Optimization of Fast Disintegrating Tablets of Atorvastatin Calcium Using Solid Dispersion Technique", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 6, page no.d735-d745, June-2023, Available :http://www.ijnrd.org/papers/IJNRD2306376.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2306376 Registration ID: 199292 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: d735-d745 Country: Bangalore, Karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2306376 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2306376 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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