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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Recent Developments in Tumor Targeting Drug Delivery Systems: A Comprehensive Review |
| Authors Name: | Udipta paul , Dhruba kishore paul , Mouly mitra |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_200283
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| Published Paper Id: | IJNRD2306500 |
| Published In: | Volume 8 Issue 6, June-2023 |
| DOI: | |
| Abstract: | Tumor targeting drug delivery systems have gained significant attention as a promising approach to improve the efficacy and safety of cancer therapies. This comprehensive review highlights recent developments in this field, encompassing various strategies and advancements. Passive targeting strategies exploit the enhanced permeability and retention effect and size-based targeting for preferential accumulation of drug-loaded carriers in tumors. Active targeting strategies utilize ligand-mediated, antibody-mediated, aptamer-mediated, and nanobody-based approaches to enhance specificity by selectively binding to tumor-specific receptors. Stimuli-responsive targeting strategies, including pH-responsive, enzyme-responsive, and temperature-responsive systems, enable triggered drug release within the tumor microenvironment. Nanoparticle-based drug delivery systems have seen remarkable progress, particularly lipid-based, polymer-based, and metal-based nanoparticles, offering improved drug encapsulation, controlled release, and enhanced targeting capabilities. Notably, nanocarriers designed for nucleic acid delivery, such as lipid nanoparticles for RNA delivery and polymeric nanoparticles for gene delivery, hold great promise for gene-based cancer therapies. .This comprehensive review provides an overview of the recent developments in this field, focusing on various strategies and technologies employed for efficient and specific drug delivery to tumor sites. |
| Keywords: | tumor targeting, drug delivery systems, passive targeting, active targeting, stimuli-responsive, nanoparticle-based, nucleic acid delivery, lipid nanoparticles, polymer-based nanoparticles, metal-based nanoparticles, exosomes, antibody-drug conjugates, peptide-based, characterization techniques, biocompatibility, safety assessment. |
| Cite Article: | " Recent Developments in Tumor Targeting Drug Delivery Systems: A Comprehensive Review", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 6, page no.e823-e831, June-2023, Available :http://www.ijnrd.org/papers/IJNRD2306500.pdf |
| Downloads: | 000118752 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2306500 Registration ID: 200283 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: e823-e831 Country: Habra, , West Bengal , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2306500 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2306500 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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