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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | ABNORMAL G6PDH AND LDH ENZYMES AS POSSIBLE SURROGATE MARKERS OF CRUDE OIL TOXICITY IN Libyodrilus violaceus. |
| Authors Name: | Erifeta O. Georgina , Eriyamremu E. George , Erifeta E. Kingsley |
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IJNRD_199807
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| Published Paper Id: | IJNRD2306510 |
| Published In: | Volume 8 Issue 6, June-2023 |
| DOI: | |
| Abstract: | Although crude oil consumption relative to other renewable energy sources has decreased modestly during the last decade, statistics still show clearly that it is still a dominant energy source in Nigeria. The Niger Delta region of Nigeria still continues to suffer grossly from crude oil pollution and environmental degradation owing to unguided spillages and ineffective clean-up procedures. Earthworm toxicity studies have been shown to be significant in understanding metal bioavailability, bio-membrane alterations, and energy metabolism of biological environmental indicators since water-soluble and water-insoluble chemicals can accumulate within their body because they bind tightly to specific sites within their body. Effect of crude oil and its fractions on some in vivo energy metabolism enzymes; Glucose 6-phosphate dehydrogenase (G6PDH) and Lactate dehydrogenase (LDH) enzymes, in the clitellum and post clitellum of earthworms were evaluated in a crude oil toxicity study carried out in Nigeria. Both enzymes have been identified as important enzymes of metabolic perturbations after exposure to petroleum hydrocarbons. The aim of this study is to ascertain the effect of the exposed toxicants in crude oil on Glucose 6-phosphate dehydrogenase (G6PDH) and Lactate dehydrogenase (LDH) enzymes of energy metabolism in the clitellum and post clitellum of Libyodrilus violaceus and to provide data that could propose these enzymes as possible early surrogate markers for monitoring crude oil toxicity. Two hundred and forty earthworms were assigned to four major groups. The first group was given deionized water and served as the control group, the other test groups were either exposed to a water-soluble fraction (WSF) or water-insoluble fraction (WIF), or the whole crude (WC). The clitellum and post-clitellum regions of the worms were excised and collected for physicochemical and biochemical analysis using standard methods. There was a dose-dependent decrease (p<0.05) in the activity of the G6PDHenzyme (from the control group to the 0.1, 0.2, and 0.3% treatment groups) except for the earthworms exposed to the WIF. It was observed in this result that there was a general increase (p<0.05) in LDH activities in all subjects exposed to the toxicants except subjects exposed to the 0.3% WIF when compared to the control animals. The alterations recorded in this study might have been due to the underlying chemical stress from all fractions due to the high content of contaminants present in the crude oil. |
| Keywords: | Crude Oil spillages, G6PDH, LDH, Libyodrilus violaceus |
| Cite Article: | "ABNORMAL G6PDH AND LDH ENZYMES AS POSSIBLE SURROGATE MARKERS OF CRUDE OIL TOXICITY IN Libyodrilus violaceus. ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 6, page no.f83-f97, June-2023, Available :http://www.ijnrd.org/papers/IJNRD2306510.pdf |
| Downloads: | 000118784 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2306510 Registration ID: 199807 Published In: Volume 8 Issue 6, June-2023 DOI (Digital Object Identifier): Page No: f83-f97 Country: Benin City, Edo, Nigeria Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2306510 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2306510 |
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