Anti-cancer activity of 1,3,4-oxadiazole and its derivative

Registration ID: IJNRD_206247

Published ID: IJNRD2310013

DOI: https://doi.org/10.5281/zenodo.12743599

KOUSIK MAPARU , RITAM MUKHERJEE , DHRITA CHATTERJEE

Oxadiazole ring , anticancer activity , HDAC , Proliferation , anti-tumor

Nowadays cancer is a leading cause of death, the most common cancers worldwide are breast, colorectal, and lung cancer. Data from the International agency for Research on Cancer (IARC) says 19.3 million new cases of cancer and 10 million deaths. Oxidaizole derivatives are compounds having 5-membered rings containing one oxygen and two nitrogen atoms such as oxacillin, sulfamethoxazole, acivicin, and cycloserine have containing oxadiazole ring . 1,3,4 oxadiazole derivatives have the demand for researchers because of their various activities such as antibacterial, anti-tumor, antiviral, and antioxidant. Nowadays there are potent medicines in the market having anticancer activity, used worldwide. Some examples of anticancer agents available in the market are bleomycin and tiazofurin. There are some various mechanisms of action of 1,3,4 oxadiazole derivatives for anticancer activity, by acting on some enzymes likes thymidylate-syn-thase, HDAC(histone deacetylase ), topoisomerase II, telomerase, thymidine phosphorylase to stop proliferation and also acting some pathways likes inhibiting telomerase activity, focal adhesion kinase(FAK) inhibitors, targeting thymidylate synthase, an inhibitor of the B-cell lymphoma 2, inhibitor of NF-kB signaling pathway and targeting tubulin polymerization. So,1,3,4-oxadiazole used as a promising anticancer drug in future.

Published Paper   E-Certificate

KOUSIK MAPARU, RITAM MUKHERJEE, & DHRITA CHATTERJEE (October-2023). Anti-cancer activity of 1,3,4-oxadiazole and its derivative. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), a84-a95. https://doi.org/10.5281/zenodo.12743599

Volume 8 Issue 10, October-2023

Pages : a84-a95

Paper Reg. ID: IJNRD_206247

Published Paper Id: IJNRD2310013

Downloads: 000121983

Research Area: Pharmacy

Country: East Medinipur , West Bengal , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310013.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310013

Crossref DOI: https://doi.org/10.5281/zenodo.12743599

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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