Evaluate the Protective and Therapeutic Approach of Methanolic Extract of Fruits of Momordica dioica and Antioxidants like Vitamin C + Vitamin E Against Valproic acid-Induced Teratogenecity in Rats

Registration ID: IJNRD_206192

Published ID: IJNRD2310043

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BLESSY ELIZABETH BABUKUTTY, DEEPAK KUMAR JHA

Momordica dioica fruits, antioxidant activity, teratogenecity, valproic acid, oxidative stress, methanolic extract, vitamin C + vitamin E, pregnancy.

The main objective of this research was to evaluate the protective and therapeutic approach of methanolic extract of fruits of Momordica dioica and antioxidants like Vit. C and Vit. E against valproic acid-induced teratogenecity in rats. The dose selection was made based on acute toxicity studies. For evaluating protective and therapeutic approach of antioxidants, the animals were allowed for mating and successful mating was determined by microscopic observation. Pregnant sixty animals were divided into 6 groups as Group I - Normal control – Normal saline (1ml/kg/day/p.o), Group II– Positive control - Valproic acid (1000 mg/kg/day/I.V), Group III – Treatment control- Animals received Valproic acid (1000 mg/kg./I.V) + Vit.C (8.3mg/kg/p.o) + Vit E (100mg/kg/p.o). Group IV- Test I MEFMD (250mg/kg/day/p.o), Group V – Test II MEFMD (500mg/kg/day/p.o), Group VI – Test III MEFMD (1000mg/kg/day/p.o). The respective groups were administered with the respective drugs from day 6-17 of gestation. The pregnancies were interrupted just prior to the calculated date of delivery and all groups were subjected to laparotomy under euthanization using pentobarbital and then were sacrificed. The rats treated with methanolic extract of fruits of Momordica dioica did not show any teratogenic activity which was evident by an increase in glutathione peroxidase and superoxide dismutase level, and decrease in lipid peroxidation level when compared to the positive control and treatment control which was further calculated statistically to evaluate the antioxidant effect of methanolic extract of fruits of Momordica dioica. In conclusion, these results illustrate the protective and therapeutic effect of Momordica dioica and vitamin C + vitamin E through its antioxidant activity against valproic acid-induced tertaogenecity.

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BLESSY ELIZABETH BABUKUTTY & DEEPAK KUMAR JHA (October-2023). Evaluate the Protective and Therapeutic Approach of Methanolic Extract of Fruits of Momordica dioica and Antioxidants like Vitamin C + Vitamin E Against Valproic acid-Induced Teratogenecity in Rats . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), a371-a380. https://ijnrd.org/papers/IJNRD2310043.pdf

Volume 8 Issue 10, October-2023

Pages : a371-a380

Paper Reg. ID: IJNRD_206192

Published Paper Id: IJNRD2310043

Research Area: Pharmacy

Author Type: Indian Author

Country: Bangalore, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310043.pdf

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