Paper Title
Development and Evaluation of Fast Dissolving Tablets of Diltiazem Hydrochloride
Article Identifiers
Registration ID: IJNRD_215185
Published ID: IJNRD2403174
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Keywords
Diltiazem Hydrochloride, Fast Dissolving Tablets, Superdisintegrants, Direct Compression Technique, Combination
Abstract
This study has been carried out with a concept of formulating the fast dissolving tablets of Diltiazem Hydrochloride using various superdisintegrants. To create the dosage form, direct compression technique was used. A total for nine formulations were developed. The combination of synthetic (2-6%) and natural superdisintegrant (2-8%) was incorporated in all the formulations. All the formulations were evaluated for precompression and post compression evaluation parameters. From the observation, it was found that all the formulations were disintegrated within the time range of 27 - 64 seconds. All the prepared formulations complied with the Pharmacopoeial standard requirements of the drug contents. The optimized formulation F6 gave the best results in disintegration time and dissolution studies as compared to other created formulations. The research concluded that the nature of the superdisintegrants influenced the rate of disintegration and drug release rate. From the study, it was assumed that combination of superdisintegrants in certain amount or ratio can enhance the disintegration time for increasing patient compliance.
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How To Cite (APA)
Pramod Kharel, Sujan Neupane, & Jaya Bahadur Ghale (March-2024). Development and Evaluation of Fast Dissolving Tablets of Diltiazem Hydrochloride. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), b661-b666. https://ijnrd.org/papers/IJNRD2403174.pdf
Issue
Volume 9 Issue 3, March-2024
Pages : b661-b666
Other Publication Details
Paper Reg. ID: IJNRD_215185
Published Paper Id: IJNRD2403174
Research Area: Pharmacy
Author Type: Foreign Author
Country: Kathmandu, Bagmati, Nepal
Published Paper PDF: https://ijnrd.org/papers/IJNRD2403174.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403174
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