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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | OVERVIEW AND FUTURE PROSPECTIVE OF AMYLOTROPHIC LATER SCLOROSIS |
| Authors Name: | Aarti Karle , Yogita Ingale , Dr. Yogesh Bafana , Mayuri Kapre , Ankita Kedar |
| Download E-Certificate: | Download |
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IJNRD_217565
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| Published Paper Id: | IJNRD2404197 |
| Published In: | Volume 9 Issue 4, April-2024 |
| DOI: | |
| Abstract: | Amyotrophic lateral sclerosis (ALS) is a fatal central nervous system neurodegenerative disease. Despite intense research, current ALS management remains suboptimal, from diagnosis to prognosis. Recognition of ALS phenotypic heterogeneity, global central nervous system dysfunction, genetic architecture, and development of novel diagnostic criteria are clarifying the spectrum of clinical presentation and facilitating diagnosis. Insights into ALS pathophysiology, identification of disease biomarkers and modifiable risks, along with new predictive models, scales, and scoring systems, and a clinical trial pipeline of mechanism-based therapies are changing the prognostic landscape. Although most recent advances have yet to translate to patient benefit, the view of ALS as a complex syndrome is already having tangible effects in the clinic. This review will outline these recent insights and discuss the status of ALS management for the general neurologist, along with future prospects, which may improve care and outcomes for ALS patients. Despite intensive research, current management of amyotrophic lateral sclerosis remains suboptimal from diagnosis to prognosis. Recognition of the phenotypic heterogeneity of amyotrophic lateral sclerosis, global CNS dysfunction, genetic architecture, and development of novel diagnostic criteria is clarifying the spectrum of clinical presentation and facilitating diagnosis. Insights into the pathophysiology of amyotrophic lateral sclerosis, identification of disease biomarkers and modifiable risks, along with new predictive models, scales, and scoring systems, and a clinical trial pipeline of mechanism-based therapies, are changing the prognostic landscape. Although most recent advances have yet to translate into patient benefit, the idea of amyotrophic lateral sclerosis as a complex syndrome is already having tangible effects in the clinic. This Seminar will outline these insights and discuss the status of the management of amyotrophic lateral sclerosis for the general neurologist, along with future prospects that could improve care and outcomes for patients with amyotrophic lateral. |
| Keywords: | Epidemiology, Amyotrophic lateral sclerosis, antioxidant or anti-inflammatory activity. |
| Cite Article: | "OVERVIEW AND FUTURE PROSPECTIVE OF AMYLOTROPHIC LATER SCLOROSIS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 4, page no.b785-b814, April-2024, Available :http://www.ijnrd.org/papers/IJNRD2404197.pdf |
| Downloads: | 00082 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2404197 Registration ID: 217565 Published In: Volume 9 Issue 4, April-2024 DOI (Digital Object Identifier): Page No: b785-b814 Country: Ahmednagar, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2404197 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2404197 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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