Synthesis and evaluation of naphthyl-xanthine derivatives as anti-obesity agents

Md Abid Sheikh , Ankit Diwan , Mahima Patawardhan , Kuldeep Ganju

Xanthine, 5-hydroxytryptamine, anti-obesity, naphthyl, hypophagic

The objective of this work was to synthesize naphthyl-xanthine derivatives and evaluate the anti-obesity action of the synthesized compounds. The synthesized compounds A1-5 were cream to light brown in color and obtained in 69-715 % yields and were soluble in chloroform. The confirmation of the structures of the compounds was done by 1H-NMR, mass and IR spectral study. A1-5 were found to be hypophagic and restrict the intake of food by the mice and the hyperphagic effect of (±) - 8- OH-DPAT was antagonized by both the synthesized compound.

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"Synthesis and evaluation of naphthyl-xanthine derivatives as anti-obesity agents", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 10, page no.a197-a206, October-2024, Available :https://ijnrd.org/papers/IJNRD2410024.pdf

Volume 9 Issue 10, October-2024

Pages : a197-a206

Paper Reg. ID: IJNRD_300951

Published Paper Id: IJNRD2410024

Downloads: 00037

Research Area: Pharmacy All

Country: Bhopal, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2410024

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2410024

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

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