PHARMACOLOGICAL EXMINATION OF HEPATOPROTECTIVE EFFECT ETHENOLIC EXTRACT OF LICORICE AND BRAHMAKALASH IN WISTER RATS
SHUBHAM PRAJAPATI
, Dr.Shobhit Prakash Srivastava
Glycyrrhiza glabra, Licorine, Pediatric Hepatitis, Hepatoprotective, Toxicity
Medicinal herbs are nature’s gift to humanity, contributing crucially to the preservation, maintenance and improvement of our health. In order to explore the hepatoprotective potential of prevalent medicinal plants, nine species were selected from different genera based on their ethnomedicinal records in treating different liver-related pathological conditions in South Asia. Besides, the available information was critically analyzed to gain new insights and directions for future investigations towards establishing such natural products as potent hepatoprotective agents or dietary supplements. The hepatoprotective activities of the species have been investigated in a wide variety of in vivo experimental models including carbon tetrachloride-, paracetamol-, iron-, mercuric chloride-, thioacetamide-, cyclophosphamide-, β-D-galactosamine-, cumene hydroperoxide-, α-naphthyl-isothiocyanate-, physical stress- and alcohol-induced hepatotoxicity in rats and mice. All the plants were consistent in their ability to possess hepatoprotective properties. As well, three bioactive isolates namely, schaftoside, echinocystic acid, and eclalbasaponin II were found to have promising hepatoprotective potential. However, extensive comparative studies are warranted in future to establish the relative hepatoprotective potentials of the nine species under discussion. Preparation of poly-herbal formulations from these plants and identification of hepatoprotective phytoconstituents from these plants might open up new avenues in the development of therapeutic hepatoprotective agents. Various liver ailments (hepatitis, fatty live, cirrhosis, liver cancer) are serious issues throughout the world, caused by viruses and hepatotoxic agents.
"PHARMACOLOGICAL EXMINATION OF HEPATOPROTECTIVE EFFECT ETHENOLIC EXTRACT OF LICORICE AND BRAHMAKALASH IN WISTER RATS", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 10, page no.c677-c685, October-2024, Available :https://ijnrd.org/papers/IJNRD2410281.pdf
Volume 9
Issue 10,
October-2024
Pages : c677-c685
Paper Reg. ID: IJNRD_301580
Published Paper Id: IJNRD2410281
Downloads: 00030
Research Area: Science and Technology
Country: -, -, India
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave
