"Development of Formulation , Physicochemical Characterization and Bioavailability Assessment of Self-Emulsifying Drug Delivery System for Enhanced Tenofovir”.

Miss. Nikude Y.M , Dr. Kale H.B , Miss. Dupade K.B. , Miss. Zine S.R. , Miss. Telange- Patil P.V.

SEDDS, Tenofovir, membrane permeability ETC.

Tenofovir (TNF) is a common component of many antiretroviral therapy regimens, but it is associated with poor membrane permeability and low oral bioavailability. To improve its oral bioavailability and membrane permeability, a self-emulsifying drug delivery system (SEDDS) was developed and characterized, and its relative bioavailability was compared to the marketed tablets (Tenof). Based on solubility and ternary phase diagram analysis, eucalyptus oil was selected as an oil phase, Kolliphor EL, and Kollisolv MCT 70 were chosen as surfactant and cosurfactant, respectively, while glycerol was used as cosolvent in surfactant mixture. Optimized SEDDS formulation F6 showed an oil droplet size of 98.82 nm and zeta potential of −13.03 mV, indicating the high stassbility of oil droplets. Differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy characterization studies were also carried out to assess the amorphous and morphological states of the drug in the prepared SEDDS formulation. The in vitro dissolution profile of SEDDS shows the rapid release of the drug. SEDDS F6 demonstrates a higher drug permeability than the plain TNF and TNF-marketed tablets (Tenof). A pharmacokinetic study in rats revealed that SEDDS F6 showed significantly higher Cmax and AUC0−t than the marketed tablets and pure drug suspension. In addition, the relative bioavailability of SEDDS formulation dramatically improved by 21.53-fold compared to marketed tablets and 66.27-fold compared to pure drugs. These findings show that SEDDS composed of eucalyptus oil, glycerol, Kolliphor EL, and Kollisolv MCT 70 could be a useful tool for enhancing physiochemical properties and oral TNF absorption. Therefore, SEDDS has shown promise in improving the oral bioavailability of poorly water-soluble drugs.

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""Development of Formulation , Physicochemical Characterization and Bioavailability Assessment of Self-Emulsifying Drug Delivery System for Enhanced Tenofovir”. ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 10, page no.c765-c783, October-2024, Available :https://ijnrd.org/papers/IJNRD2410292.pdf

Volume 9 Issue 10, October-2024

Pages : c765-c783

Paper Reg. ID: IJNRD_301235

Published Paper Id: IJNRD2410292

Downloads: 0008

Research Area: Pharmacy All

Country: Aurangabad., Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2410292

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2410292

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

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