ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SOLIFENACIN SUCCINATE BY USING UV-SPECTROPHOTOMETRIC METHOD

SAHANA R , VARSHA G P , SNEHA C K , PUNITH GOWDA A U , SADHAN S

Solifenacin succinate, validation ,zero order derivative spectroscopy, ICH Guidelines

Simple, precise and accurate zero order derivative spectroscopic method has been developed and validated for the estimation of Solifenacin succinate in bulk and pharmaceutical dosage form. The drug shows maximum absorption (λ max) at 225nm in 0.1N H2SO4 solution and obeys Beer’s law in the concentration range of 2-10µg/ml. The linearity study was carried out and regression coefficient was found to be 0.9999 and it showed good linearity, precision during this concentration range. The % recovery was found to be 99-101.39%. The LOD and LOQ were found to be 0.0607 µg/ml and 0.203/ml. The % relative standard deviation (%RSD) was found to be less than 2. According to ICH guidelines the technique has been validated for linearity, precision, accuracy, ruggedness, LOD and LOQ. The developed and validated method can be successfully applied for routine quantification of Solifenacin succinate in bulk and pharmaceutical dosage form.

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"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SOLIFENACIN SUCCINATE BY USING UV-SPECTROPHOTOMETRIC METHOD", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 10, page no.d9-d17, October-2024, Available :https://ijnrd.org/papers/IJNRD2410302.pdf

Volume 9 Issue 10, October-2024

Pages : d9-d17

Paper Reg. ID: IJNRD_301573

Published Paper Id: IJNRD2410302

Downloads: 00017

Research Area: Science and Technology

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2410302

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2410302

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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