COMPARATIVE STUDY OF BETA-LACTAM MONOTHERAPY VERSUS COMBINATION OF BETA-LACTAM ALONG WITH OTHER ANTIBIOTIC THERAPY FOR THE TREATMENT OF LRTI IN PEDIATRICS.

Registration ID: IJNRD_301876

Published ID: IJNRD2411103

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Bakshi Divya, Anaswara C, B.Saikiran, Bhuvana S, Dr. Lokesh S V

Beta lactam antibiotics, LRTI, monotherapy, combination therapy, PRESS score.

COMPARATIVE STUDY OF BETA-LACTAM MONOTHERAPY VERSUS COMBINATION OF BETA-LACTAM ALONG WITH OTHER ANTIBIOTIC THERAPY FOR THE TREATMENT OF LRTI IN PEDIATRICS Short title: Comparison of antibiotics used in LRTI in Pediatrics. Abstract: Background: This study was done to compare the effectiveness of Beta lactam monotherapy versus combination of Beta lactam along with other antibiotics therapy for treating the LRTI in Pediatrics. A total of 75 patients included in this study who are of age between 3 months to 18 years. The most frequent presenting complaints were cough, fever, and breathlessness, signifying the serious condition of the patient, requiring hospitalization. The common diagnosis are Pneumonia and Bronchiolitis. Objectives: The primary objective of this study is to compare the effectiveness and tolerability of β-Lactam monotherapy Vs combination of β-Lactam along with other antibiotics therapy for the treatment of LRTI in Pediatrics and to compare the duration of hospital, stay on β-Lactam monotherapy Vs combination of β-Lactam along with another antibiotics therapy. Materials and methods: The present study was conducted in Pediatric department of BGS Global Institute of Medical Sciences (BGS-GIMS), Kengeri, Bengaluru, Karnataka. This is a comparative study of monotherapy vs combination therapy of beta lactam antibiotics in LRTI and the study was conducted for the period of 6 months. All children within the age of 3 month to 18 years admitted with LRTI in a pediatric department were included in the study. Results: Our study compares the effectiveness of monotherapy vs. combination therapy with commonly prescribed antibiotics for LRTI in children, primarily Ceftriaxone, Amoxicillin + Clavulanic acid, and Azithromycin. Most children recover fully, with a small portion developing chronic symptoms due to factors like immunosuppression and environmental conditions. Hospital stays and recovery times were similar between groups, with no significant difference in duration. Monotherapy had a higher pneumonia classification rate (48.1% vs. 38.1%) and underweight status (77.8% vs. 81%) compared to combination therapy. The PRESS score showed significant differences only on the first day of follow-up. Interpretation & Conclusions: Over all in the comparison between the beta lactam monotherapy and combination of beta lactam along with other antibiotic therapy we concluded that there was no significant difference between the both of them. Both are effective in the patients for their respective situation and can chose based on the benefit over risk to the patient.

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Bakshi Divya, Anaswara C, B.Saikiran, Bhuvana S, & Dr. Lokesh S V (November-2024). COMPARATIVE STUDY OF BETA-LACTAM MONOTHERAPY VERSUS COMBINATION OF BETA-LACTAM ALONG WITH OTHER ANTIBIOTIC THERAPY FOR THE TREATMENT OF LRTI IN PEDIATRICS.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(11), b34-b54. https://ijnrd.org/papers/IJNRD2411103.pdf

Volume 9 Issue 11, November-2024

Pages : b34-b54

Paper Reg. ID: IJNRD_301876

Published Paper Id: IJNRD2411103

Research Area: Pharmacy All

Author Type: Indian Author

Country: Sangareddy, Telagana, India

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