A PROSPECTIVE OBSERVATIONAL STUDY OF EVALUATION OF PRESCRIPTION PATTERN OF ANTIBIOTIC AND THEIR EFFECTIVENESS IN RESPIRATORY TRACT INFECTION PATIENTS

Registration ID: IJNRD_302440

Published ID: IJNRD2412015

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Bindu A, Md. Mohsin Abrar shah, Ramya M, Shany Shaju, Dr. Pooja N Y

Prescription pattern, antibiotics, respiratory tract infections, drug effectiveness, culture sensitivity, hospitalized patients.

Abstract: Background: Respiratory tract infections (RTIs) are one of the most common reasons for antibiotic prescriptions worldwide. However, inappropriate use of antibiotics in RTI management contributes to the growing concern of antibiotic resistance. This study aims to evaluate the prescription patterns of antibiotics and their clinical effectiveness in treating patients with RTIs. Objectives: To study and analyze about drug utilization pattern and their effectiveness of antibiotics prescribed for RTI patients in a hospital. Materials and methods: This prospective observational study was conducted for a six-month period at a tertiary care hospital. A total of 152 patients diagnosed with various types of RTIs [upper respiratory tract infections (URTIs), lower respiratory tract infections (LRTIs), and pneumonia] were included. Patient demographics, clinical manifestations, antibiotic prescriptions, and laboratory results (including microbial cultures and sensitivity tests) were documented. The effectiveness of prescribed antibiotics was evaluated based on clinical outcomes, resolution of symptoms, and microbiological cure. Result: Out of 152 patients, the majority receiving broad-spectrum agents, including ceftriaxone, piperacillin-tazobactam, and sulbactum-cefoperazone. The most common diagnoses were pneumonia (36.18%), LRTIs (26.97%), Chronic Obstructive Pulmonary Disease (COPD) (14.47%), Tuberculosis (TB) (9.21%), respiratory failure (9.21%), bronchitis (7.89%), bronchial asthma (6.58%), URTIs (6.58%), pharyngitis (2.63%), Acute Respiratory Distress Syndrome (ARDS) (1.32%), pleural effusion (1.32%). Percentage of oral antibiotic prescribed was 41.45% and antibiotic injection was 58.55%. Percentage of the antibiotic from National List of Essential Medicine (NLEM) was 61.66% and fixed dose combinations prescribed were 9.54%. Percentage of antibiotics replaced was 5.18%. Percentage of the antibiotics prescribed by generic name were low and has to improved. Interpretation and conclusions: The study highlights a prevalent over-reliance on broad-spectrum antibiotics for RTI management, often without microbiological confirmation. The effectiveness of narrow spectrum was similar to effectiveness of broad-spectrum antibiotics therapy in RTI patients. Ceftriaxone was the most prescribed Broad- spectrum antibiotic. Clarithromycin is most commonly prescribed narrow spectrum antibiotic. Patients experienced no significant side effects for both broad and narrow spectrum antibiotics during their hospital stay. Physicians prescribed IV antibiotics for fast relief from symptoms. The hospital followed standard prescribing guidelines by considering the sensitivity pattern of organisms in the locality to promote rational prescribing.

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Bindu A, Md. Mohsin Abrar shah, Ramya M, Shany Shaju, & Dr. Pooja N Y (December-2024). A PROSPECTIVE OBSERVATIONAL STUDY OF EVALUATION OF PRESCRIPTION PATTERN OF ANTIBIOTIC AND THEIR EFFECTIVENESS IN RESPIRATORY TRACT INFECTION PATIENTS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(12), a123-a127. https://ijnrd.org/papers/IJNRD2412015.pdf

Volume 9 Issue 12, December-2024

Pages : a123-a127

Paper Reg. ID: IJNRD_302440

Published Paper Id: IJNRD2412015

Research Area: Pharmacy All

Author Type: Indian Author

Country: Bangalore, karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2412015.pdf

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