Prospective Analysis of NSAID Utilization and Adverse Events in a Tertiary Care Hospital

Registration ID: IJNRD_303583

Published ID: IJNRD2501250

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Sushmitha K, Tejashwini R, Ritika Shukla, Vaisakh U P, Dr. Lokesh S V

Key words: NSAID’S, ADR, Renal damage, GI bleeding, NSAID toxicity, DUE

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for management of both acute pain and chronic pain and inflammatory disorders such as rheumatoid arthritis and osteoarthritis. It is also known to cause various adverse effects. NSAIDs are agents having analgesic, antipyretic and anti-inflammatory effects which are most widely used class of drug worldwide.According to WHO ADR is defined as noxious, unintended effect of drug which occurs at normal dose in humans for prophylaxis, diagnosis or therapy of disease.The most commonly prescribed NSAIDs are paracetamol, aspirin, ibuprofen. Objectives: To analyse the prescribing pattern of NSAID’s and to analyse the ADR profile of NSAID’s in tertiary care hospital. Materials and methods: This is a prospective study carried out in the General Medicine Ward for a period of 6 months. The Drug Utilisation pattern of NSAID’s and ADR reporting of all the adult patients (≥18 years of age) of both genders needed to be assessed is included in the study. Vulnerable subjects were excluded from the study. Results: Out of the 208 patients, the distribution of males and females were found to be 108 and 100respectively. This study shows that 30.30% of patients received paracetamol,20.20% patient received diclofenac,4.80% patient received naproxen,8.20% patient received aceclofenac +PCT ,6.70% patient received ibuprofen +PCT, 5.30% patient received mefenamic acid + PCT, 7.70% patient received diclofenac+PCT. By this we get to know that the number of patients who were receiving the drug paracetamol are highest i.e, 30.3% and the number of patients who were receiving the drug naproxen are leas`t i.e,3.40%. Among the combination drugs studied so far, patient received aceclofenac+PCT 8.20% was found to be highest and mefenamic acid +PCT was found to be least 5.30%. Interpretation and Conclusions: Renal tests, liver panel, and CBC are among the recommended monitoring procedure. Patient who are not thought to be at high risk of NSAID toxicity are less likely to be monitored. People with renal or hepatic issues, NSAID use must be monitored or is contraindications. Hepatotoxicity, hypertension, renal damage and GI bleeding are some of the symptoms of NSAID toxicity.

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Sushmitha K, Tejashwini R, Ritika Shukla, Vaisakh U P, & Dr. Lokesh S V (January-2025). Prospective Analysis of NSAID Utilization and Adverse Events in a Tertiary Care Hospital. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(1), c376-c384. https://ijnrd.org/papers/IJNRD2501250.pdf

Volume 10 Issue 1, January-2025

Pages : c376-c384

Paper Reg. ID: IJNRD_303583

Published Paper Id: IJNRD2501250

Downloads: 000121988

Research Area: Pharmacy All

Author Type: Indian Author

Country: Mysore , karnataka , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2501250.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2501250

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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