EVALUATION OF TREATMENTS FOR SACROILITIS IN SPONDYLOARTHROPATHY USING THE SPONDYLOARTHRITIS RESEARCH CONSORTIUM CANADA SCORING SYSTEM - A PROSPECTIVE COHORT STUDY

Registration ID: IJNRD_303606

Published ID: IJNRD2501256

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ASHISH SACHDEVA

SIJ - Sacroiliac joint

Background In this study, the Spondyloarthritis Research Consortium Canada (SPARCC) scoring method was used to compare treatment methods in patients with axial spondyloarthritis (SpA), a form of sacroiliitis. MRI abnormalities in bone marrow edema (BME) were compared before and after treatment in order to compare the efficacy of anti-TNF-α and DMARD, alone or in combination, as treatments for sacroiliitis. Methods 100 patients with axial SpA (mean age 22.6 years) were recruited. Patients were divided into three groups according to different treatments (anti-TNF-α alone vs. DMARDs alone vs. combined anti-TNF-α and DMARDs). MRI examinations were performed before and after treatment. The SPARCC score, clinically relevant AS Disease Activity (ASDAS) indices, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were analyzed. Results After treatment, ASDAS and SPARCC scores, ESR, and CRP were significantly improved (P < 0.05) in the anti-TNF-α monotherapy and combination groups; however, there were no statistically significant differences (P > 0.05) in clinical disease activity and radiological inflammation of sacroiliac joint (SIJ) in patients in the DMARDs alone group. SPARCC showed a correlation with ASDAS score pre-treatment, but not post-treatment. Furthermore, there were significant changes (P < 0.05) in these patients with axial SpA after only 3 months of treatment. Follow-up studies of patients who continued therapy for 4-6 months and 9-12 months revealed statistically significant differences from baseline (P < 0.05). Conclusions SPARCC can be used to assess severity of disease pre-treatment. Anti-TNF-α treatment resulted in effective reduction of disease activity and BME of SIJ after 3 months of therapy.

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ASHISH SACHDEVA (January-2025). EVALUATION OF TREATMENTS FOR SACROILITIS IN SPONDYLOARTHROPATHY USING THE SPONDYLOARTHRITIS RESEARCH CONSORTIUM CANADA SCORING SYSTEM - A PROSPECTIVE COHORT STUDY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(1), c458-c463. https://ijnrd.org/papers/IJNRD2501256.pdf

Volume 10 Issue 1, January-2025

Pages : c458-c463

Paper Reg. ID: IJNRD_303606

Published Paper Id: IJNRD2501256

Research Area: Health Science All

Author Type: Indian Author

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