Paper Title
STUDY OF ANTIBIOTIC RESISTANCE PROFILE OF PATIENTS WITH RESPIRATORY TRACT INFECTIONS IN SMIMER, SURAT, GUJARAT
Article Identifiers
Registration ID: IJNRD_304374
Published ID: IJNRD2503187
: http://doi.one/10.1729/Journal.44178
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Keywords
antibiotic resistance, MDR, respiratory tract infection,
Abstract
Background and Objective: Respiratory tract infections (RTIs) are one of the leading human diseases causing high morbidity and mortality worldwide. Day by day, the prevalent etiological agents which causes Respiratory infection and their antimicrobial resistance patterns varies geographically. It is important to study their recent trends for ideal treatment and effective management. Materials and Methods: For original research, clinical samples including Sputum, Pleural fluid, Tracheal aspirate, and BAL fluid from respiratory tract were examined for culture and sensitivity reports. The samples were obtained in the microbiology lab, Department of Microbiology, SMIMER during 1st August 2022 - 31st may 2023. The samples were processed by standard methods for isolation and identification. Antibiotic sensitivity test was done by using Kirby Bauer disc diffusion method and results were interpreted according to CLSI 2022 guidelines. Results: Total 650 samples were collected from which, 439 (67.53%) clinical samples were shown positive for bacterial growth from total 650 clinical samples for. Total 540 isolates were obtained from 439 positive samples in which 450 (83.3%) isolates were gram-negative bacilli (GNB) and 90 (16.6%) isolates were gram-positive cocci. The predominant pathogen isolated was K. pneumoniae (31.66%) followed by P. aeruginosa (17.40%). The overall susceptibility of GNB was highest towards macrolide followed by penicillin, cephalosporin. Gram positive organisms exhibited highest susceptibility towards Vancomycin and Linezolid. 31% of Staphylococcus aureus were Methicillin Resistant (MRSA). Most of the isolates shows high level of resistance against more than two antibiotics. Although multi-drug resistance was also reported in the present study. Gentamicin, Amikacin and Cefuroxime are recommended as the antibiotics of choice for the treatment against bacterial isolates obtained. Conclusion: Ertapenem and Meropenem is the most sensitive antibiotics followed by Amikacin and Linezolid which can be used for empirical therapy for RTI. The antibiotic therapy should be modified as per the culture and antibiotic sensitivity report. Regular determinations of the type of bacterial pathogens and updating of antibiogram must be followed in every institution to aid in better patient management by helping the clinician in the proper use of antibiotics.
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How To Cite (APA)
Bhavika Kaklotar & Dr. Mayuri Dholaria (March-2025). STUDY OF ANTIBIOTIC RESISTANCE PROFILE OF PATIENTS WITH RESPIRATORY TRACT INFECTIONS IN SMIMER, SURAT, GUJARAT. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(3), b682-b689. http://doi.one/10.1729/Journal.44178
Issue
Volume 10 Issue 3, March-2025
Pages : b682-b689
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Paper Reg. ID: IJNRD_304374
Published Paper Id: IJNRD2503187
Research Area: Life Sciences All
Author Type: Indian Author
Country: surat, Gujarat, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2503187.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2503187
Crossref DOI: http://doi.one/10.1729/Journal.44178
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