Paper Title
Review on: Self Micro-Emulsifying Drug Delivery System for Poorly Water Soluble Drug”
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Registration ID: IJNRD_305787
Published ID: IJNRD2504403
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Keywords
Biopharmaceutical, Co-surfactant, Bioavailability, SMEDDS, lipophilic, ETC.
Abstract
Oral route is the most convenient route of drug administration in many diseases and till today it is the first way investigated in the development of new dosage forms. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility, thereby pretense problems in their formulation. More than 40% of potential drug products suffer from poor water solubility. For the therapeutic delivery of lipophilic active moieties (biopharmaceutical classification system Class II drugs), lipid-based formulations are inviting increasing attention. Currently, a number of technologies are available to deal with the poor solubility, dissolution rate, and bioavailability of insoluble drugs. One of the promising techniques is self-microemulsifying drug delivery systems (SMEDDS). SMEDDS have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents, and co-solvents/surfactants can be used for the design of formulations to improve the oral absorption of highly lipophilic drug compounds. Conventional SMEDDS are mostly prepared in a liquid form, which can have some disadvantages. SMEDDS can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water emulsions. Solid-SMEDDS are prepared by solidification of liquid/semisolid self-micron emulsifying ingredients into powders, have gained popularity. This article gives a complete overview of SMEDDS,
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How To Cite (APA)
Mr. Ladkat Shripad.S., Dr. Phade Swapnil. A., & Miss. Telange - Patil Pooja. V. (April-2025). Review on: Self Micro-Emulsifying Drug Delivery System for Poorly Water Soluble Drug”. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(4), e12-e25. https://ijnrd.org/papers/IJNRD2504403.pdf
Issue
Volume 10 Issue 4, April-2025
Pages : e12-e25
Other Publication Details
Paper Reg. ID: IJNRD_305787
Published Paper Id: IJNRD2504403
Research Area: Pharmacy All
Author Type: Indian Author
Country: Solapur, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2504403.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2504403
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