Paper Title
OPTIMIZATIONANDEVALUATIONOF TOPICAL GEL CONTAINING SOLIDLIPID NANOPARTICLES LOADED WITH LULICONAZOLE
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Registration ID: IJNRD_306604
Published ID: IJNRD2505161
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Keywords
; Solid Lipid Nanoparticles (SLNs), Luliconazole, zeta potential, Quality by Design.
Abstract
Luliconazole, an imidazole-class antifungal agent, has demonstrated potent activity against a broad spectrum of dermatophytes and yeasts, making it highly effective for the treatment of superficial fungal infections. Despite its promising therapeutic profile, the conventional topical formulations of luliconazole often face limitations such as poor skin retention, suboptimal drug penetration, and short duration of action, which can affect patient compliance and treatment efficacy. These limitations necessitate the development of advanced drug delivery systems that can enhance the therapeutic performance of luliconazole for topical applications.Solid Lipid Nanoparticles (SLNs) have emerged as a promising nanocarrier system for topical drug delivery due to their ability to encapsulate lipophilic drugs, improve drug stability, and provide controlled release. Their solid lipid matrix ensures biocompatibility, enhances skinpermeation, and allows for sustained drug release at the site of action. Incorporating luliconazoleloaded SLNs into a gel base further enhances its applicability by improving the formulation's spreadability, patient acceptability, and site-specific delivery. This review focuses on the formulation strategies, optimization techniques, and evaluation parameters associated with SLN-loaded luliconazole gels. It discusses various formulation approaches, such as the selection of lipids and surfactants, methods of preparation, and design of experiments (DoE) for optimizing critical quality attributes like particle size, zeta potential, drug entrapment efficiency, and viscosity.
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How To Cite (APA)
Vaibhav shukla & Akahay kumar (May-2025). OPTIMIZATIONANDEVALUATIONOF TOPICAL GEL CONTAINING SOLIDLIPID NANOPARTICLES LOADED WITH LULICONAZOLE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(5), b616-b626. https://ijnrd.org/papers/IJNRD2505161.pdf
Issue
Volume 10 Issue 5, May-2025
Pages : b616-b626
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Paper Reg. ID: IJNRD_306604
Published Paper Id: IJNRD2505161
Research Area: Pharmacy All
Author Type: Indian Author
Country: roorkee, Uttarakhand, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2505161.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2505161
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