INVESTIGATING ADVANCES IN SELF EMULSIFYING DRUG

Registration ID: IJNRD_306508

Published ID: IJNRD2505481

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Abhishek kumar, Ms. Aditi Bhardwaj, Aakrshan kumar, Parveen kumar

Keywords:- Aqueous solubility, Self-emulsifying drug delivery system (SEDDS, Isotonic mixtures

ABSTRACT: The solubility of orally administered pharmaceuticals is a major challenge for the pharmaceutical industry because around 35–40% of newly approved drugs have low water solubility, which causes poor dissolution and high intra- and inter-subject variability. and inadequate bioavailability results in an imbalance in dosage proportionality. This could rise as a result of various processes such the formation of salt, solid dispersion, and complicated construction. The Self-Emulsifying Drug Delivery System (SEDDS) is being more widely used to improve the solubility of lipophilic medications. G1 fluids are an example of an aqueous medium. SEDDS are described as isotropic mixtures of one or more hydrophilic solvents, co-solvents, and/or surfactants that, when gently shaken and then diluted in water, have the unusual ability to generate fine oil-in-water (o/w) micro emulsions. SEDDS are defined as isotropic mixes of one or more hydrophilic solvents, co-solvents, and surfactants that, when gently stirred and then diluted in water, have the remarkable capacity to create fine oil-in-water (o/w) micro emulsions. GI fluids are an example of an aqueous medium. Typically designed in liquid or solid dosage forms like tablets, capsules, or pellets, SEDDS provide a number of benefits, such as increased drug permeability, better drug solubility, and protection against drug degradation in the gastrointestinal tract. Additionally, they offer versatility in terms of choosing lipids, surfactants, and co-surfactants, enabling the formulation to be tailored to the unique physiochemical characteristics of the medication. A broad variety of pharmacological classes, including lipophilic, poorly soluble, and low bioavailability medications like immunosuppressant, lipid-lowering medicines, anticancer treatments, and antiviral products, have been effectively treated using SEDDS.

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Abhishek kumar, Ms. Aditi Bhardwaj, Aakrshan kumar, & Parveen kumar (May-2025). INVESTIGATING ADVANCES IN SELF EMULSIFYING DRUG. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(5), e719-e724. https://ijnrd.org/papers/IJNRD2505481.pdf

Volume 10 Issue 5, May-2025

Pages : e719-e724

Paper Reg. ID: IJNRD_306508

Published Paper Id: IJNRD2505481

Research Area: Pharmacy All

Author Type: Indian Author

Country: ludhiana, punjab, India

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