A Case Report On Parkinsonism- Porencephalic Cavity With Gliosis

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Published ID: IJNRD2507187

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Swaminath G Iyer, Sebin S Varghese, Drishya L, Chintha Chandran, Shaiju S Dharan

Porencephalic cavities, Gliosis, Cerebrospinal Fluid, Parkinsons Disease, Dopaminergeic

Porencephalic cavities or cysts are rare cerebrospinal fluid-filled spaces that result from the destruction or loss of brain tissue, often due to ischemic events, hemorrhages, or congenital malformations. Gliosis, a reactive process which is marked by the proliferation of the glial cells in the brain on response to brain injury, which typically accompanies with these structural lesions. When combined, these abnormalities can lead to motor dysfunction resembling Parkinson’s disease (PD), which is a neuro degenerative disorder predominantly affecting dopaminergic neurons in the substantia nigra of the brain. In the case of this 67-year-old patient, the presentation of parkinsonism alongside porencephalic cavities and gliosis suggests a potential disruption in the basal ganglia circuitry, a critical network involved in motor control. Neuroimaging revealed a porencephalic cavity in the right fronto-parietal region with surrounding gliosis with hemosiderin residue, which may contribute to impaired neural connectivity and exacerbation of parkinsonism symptoms such as bradykinesia, rigidity, and tremor. The age of the patient further worsens the complexity, as the degenerative changes associated with both age-related Parkinson’s disease and the structural brain abnormalities could interact, complicating the diagnosis and its treatment. The patient also mentions about disease history of type 2 Diabetes Mellitus and Hypertension which further worsens his condition. Conventional dopaminergic therapy are often only the mainstay for Parkinsons Disease, may be less effective due to the involvement of structural brain damage, thus requiring a tailored and patient centered treatment approach. This case highlights the complex interplay between vascular risk factors and structural brain damage in the pathogenesis of parkinsonism. It shows the importance of a multidisciplinary approach combining neurologic, metabolic, and rehabilitative strategies.

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Swaminath G Iyer, Sebin S Varghese, Drishya L, Chintha Chandran, & Shaiju S Dharan (July-2025). A Case Report On Parkinsonism- Porencephalic Cavity With Gliosis. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(7), b813-b816. https://ijnrd.org/papers/IJNRD2507187.pdf

Volume 10 Issue 7, July-2025

Pages : b813-b816

Paper Reg. ID: IJNRD_308262

Published Paper Id: IJNRD2507187

Research Area: Pharmacy All

Author Type: Indian Author

Country: Thiruvananthapuram, Kerala, India

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