Formulation and evaluation of mangiferin loaded transdermal patches for sustained release and improved bioavailability

Registration ID: IJNRD_311066

Published ID: IJNRD2512135

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Shivam Singh, Ran Vijay Singh, Sanjay Kumar Kushwaha

Mangiferin, transdermal, drug delivery, eudragit, bioavailability

In the present study the prime objective was to develop transdermal patches loaded with mangiferin in order to improve its bioavailability by sustaining the drug release. Transdermal patches were prepared using Hydroxy propyl methyl cellulose (HPMC K) as the hydrophilic matrix and eudragit (ER) as the lipophilic component. The pH levels of the patches ranged between 5. .31 ± 0.006 to 5.64 ± 0.015. The thickness of the transdermal patches ranged from 0.513 ± 0.004 mm to 0.693 ± 0.004 mm. The formulated transdermal patches displayed average weight between 191.33 ± 0.577 mg and 238.67 ± 2.032 mg. The moisture content of the formulated transdermal patches varied from 7.15 ± 0.058 % to 10.15 ± 0.158 %. The formulated transdermal patches displayed tensile strength values between 9.51 ± 0.006 kg/cm2 and 10.46 ± 0.015 kg/cm2, which were within the acceptable limits for transdermal patches. The drug content ranged from 93.5 ± 0.404 % to 97.3 ± 0.153 %. The in vitro drug release study depicted that the highest amount of drug was released from T9 (86.01 ± 1.033 %) while the lowest was released from T5 (55.27 ± 2.032 %) at the end of 24 hours of release study.

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Shivam Singh, Ran Vijay Singh, & Sanjay Kumar Kushwaha (December-2025). Formulation and evaluation of mangiferin loaded transdermal patches for sustained release and improved bioavailability. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(12), b278-b287. https://ijnrd.org/papers/IJNRD2512135.pdf

Volume 10 Issue 12, December-2025

Pages : b278-b287

Paper Reg. ID: IJNRD_311066

Published Paper Id: IJNRD2512135

Research Area: Pharmacy All

Author Type: Indian Author

Country: Ayodhya, Uttar Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2512135.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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