Formulation and characterization of solid lipid nanoparticles of naringenin

Registration ID: IJNRD_311094

Published ID: IJNRD2512137

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Adarsh Mishra, Ran Vijay Singh, Sanjay Kumar Kushwaha

Naringenin, sustained release, half-life, solid lipid nanoparticles, nanoprecipitation

Naringenin is a natural antioxidant isolated for Grapefruit and is known to possess a large number of pharmacological actions. The half-life of the molecule is though low (2.6-3.0h) which limits the use of the molecule in therapy. The objective of the present work was to formulate solid lipid nanoparticles loaded with naringenin for improving bioavailability of naringenin. The SLNs loaded with naringenin were prepared by using different ratio of palmitic and stearic acid as the lipids and Tween 80 as the surfactant using nanoprecipitation technique. The size range of SLNs obtained on sonicating for 25 was found to be 163.6 nm when stearic acid was used and 142.2 nm when palmitic acid was used for the preparation of SLNs. The zeta potential of all the SLNs ranged from -2.79 to -25.9 mV suggesting most stable formulation NSLN-7. The highest encapsulation of naringenin (79.3%) was obtained when the concentration of palmitic acid was 1.6 mmol. The in vitro release of naringenin from the SLNs was measured by dialysis method using phosphate buffer as the dissolution medium. In vitro release kinetics studies for naringenin loaded SLNs exhibited a sustained release pattern. Sustained release was observed over a period of 3 days. The stability of NSLN-7 was studied by storing at 4 ± 1 °C for 30 days. The particle size remained stable at the end of the study with drug entrapment of 67.4%.

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Adarsh Mishra, Ran Vijay Singh, & Sanjay Kumar Kushwaha (December-2025). Formulation and characterization of solid lipid nanoparticles of naringenin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 10(12), b328-b337. https://ijnrd.org/papers/IJNRD2512137.pdf

Volume 10 Issue 12, December-2025

Pages : b328-b337

Paper Reg. ID: IJNRD_311094

Published Paper Id: IJNRD2512137

Research Area: Pharmacy All

Author Type: Indian Author

Country: Ayodhya, Uttar Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2512137.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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