Neolamarckia cadamba and Kidney Health: A Review on its Antioxidant and Anti-fibrotic Phytochemical Promise

Registration ID: IJNRD_311814

Published ID: IJNRD2601178

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Rahul Lohan, Aditya Kumar

Neolamarckia cadamba, Chronic Kidney Disease, Renal Fibrosis, Oxidative Stress, Nrf2 Pathway, Anti-fibrotic

Chronic Kidney Disease (CKD) is increasingly getting of concern because continued destruction of kidney by continued oxidative stress and inflammation is irreversible and current methods of control are insufficient to halt this process. N. cadamba that has industrial application in traditional medicine in treatment of wounds, fevers and inflammation has various bioactive compounds including cadambagenic acid, quinovic acid, indole alkaloids, phenolics and flavonoids. The significance of these natural antioxidants is due to the fact that oxidative damage has a significant role to play in CKD. Recent cell and animal studies demonstrate that N. cadamba extracts have the capability of interacting with the Keap1-Nrf2-ARE pathway, which enhances the antioxidant defence of the body such as HO-1, NQO1, catalase, and SOD. N. cadamba can be useful in reducing the cell damage by reactive oxygen species in the kidney cells by raising the level of these enzymes. The review examines how the plant can counter oxidative stress as well as fibrosis that are one of the major contributors to CKD that begins when the kidney fibroblasts transform and synthesize excess of the matrix because of TGF-1. Even though few studies have been conducted on the anti-fibrotic effects of N. cadamba in kidney models, its compounds have demonstrated high anti-inflammatory effects including inhibiting NF-KB and the down regulation of inflammatory cytokines like IL-6 and TNF-a. This could assist in breaking the perpetration of inflammation and fibrosis. Other organs have already demonstrated the anti-fibrotic action of terpenoids and chlorogenic acid of N. cadamba, so that they may also provide help to the kidneys. In general, the existing data indicate that N. cadamba may be a potential solution to new CKD therapies by enhancing the antioxidant defences and decreasing the inflammation. More studies should be conducted to identify the most promising anti-fibrotic agents and to evaluate whether they are able to prevent or restore kidney damage in CKD.

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Rahul Lohan & Aditya Kumar (January-2026). Neolamarckia cadamba and Kidney Health: A Review on its Antioxidant and Anti-fibrotic Phytochemical Promise. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(1), b591-b602. https://ijnrd.org/papers/IJNRD2601178.pdf

Volume 11 Issue 1, January-2026

Pages : b591-b602

Paper Reg. ID: IJNRD_311814

Published Paper Id: IJNRD2601178

Research Area: Pharmacy All

Author Type: Indian Author

Country: Muzaffarnagar , Uttar Pardesh, India

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