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Research Paper
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Paper Title

Introduction to pharmacovigilance and study of Adverse drug reaction of antimalarial drug

Article Identifiers

Registration ID: IJNRD_312185

Published ID: IJNRD2602032

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Keywords

Pharmacovigilance, pharmacy, pharmacist, adverse drug reaction reporting, health system, rational use of medicine, pharmacotherapy, antimalarial drugs

Abstract

Pharmacovigilance plays a crucial role in monitoring adverse drug reactions (ADRs) associated with antimalarial drugs, particularly given the ongoing public health challenges posed by malaria in tropical and subtropical areas. Although antimalarial medications are essential for both the treatment and prevention of malaria, their use can lead to various ADRs that affect treatment efficacy and patient safety. This study reviews the ADRs linked to commonly utilized antimalarial drugs, including chloroquine, quinine, primaquine, mefloquine, sulfadoxine-pyrimethamine, and artemisinin-based combination therapies (ACTs).Data were sourced from published literature, World Health Organization (WHO) reports, and pharmacovigilance databases. The analysis reveals that chloroquine is commonly associated with gastrointestinal disturbances and retinal toxicity, while quinine can notably cause cinchonism and hypoglycemia. Primaquine poses a risk of hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Generally, ACTs exhibit favorable safety profiles, although mild neurological and gastrointestinal effects have been noted. Additionally, some medications, like sulfadoxine-pyrimethamine, can lead to severe cutaneous reactions.Furthermore, the study highlights the urgent need for robust pharmacovigilance systems and emphasizes the importance of early detection and regular reporting of ADRs to ensure the safe administration of antimalarial drugs. Strengthening ADR monitoring mechanisms is critical for reducing drug-related morbidity and enhancing patient outcomes in regions where malaria is endemic.

How To Cite (APA)

Prerna R Jadhav, Bhagyashri G Gayake, Kaushik K Kamble, Ashwini Pundkar, & Dr.Payghan Santosh (February-2026). Introduction to pharmacovigilance and study of Adverse drug reaction of antimalarial drug . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(2), a297-a308. https://ijnrd.org/papers/IJNRD2602032.pdf

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Other Publication Details

Paper Reg. ID: IJNRD_312185

Published Paper Id: IJNRD2602032

Research Area: Pharmacy All

Author Type: Indian Author

Country: aurangabad, maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2602032.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2602032

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Publication Timeline

Paper Submission
27-01-2026
Peer Review
Through Scholar9.com Platform
Paper Acceptance
03-02-2026
Paper Publication
06-02-2026

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