Paper Title
A Review on Floating Microspheres of Teneligliptin
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Registration ID: IJNRD_323609
Published ID: IJNRD2604478
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Keywords
Floating microspheres, Teneligliptin, In-vitro release, Bioavailability, pre-clinical study (in vivo)
Abstract
Teneligliptin is one of the newly approved gliptins and is effective in treating type-2 diabetes. It is hypothesized that an oral formulation that could substantially retain in the gastrointestinal tract (GIT) and release the drug in a controlled manner could be highly effective than a single dose conventional dosage form. The purpose of the present investigation is the development and characterization of gastro-retentive floating drug delivery system for anti-diabetic drug “Teneligliptin” that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time leading to improved bioavailability. Different formulations of Teneligliptin would be prepared as the floating microspheres using Ethylcellulose polymer by emulsion solvent evaporation technique. The dried floating microspheres would be evaluated for a drug content, particle size analysis, incorporation efficiency, floating behavior and in-vitro drug release studies. The developed gastro retentive floating drug delivery system of Teneligliptin must show excellent physicochemical properties and controlled drug release pattern, thereby improving the bioavailability of the drug and also manage the complicacy of the diabetes in a better manner. In conclusion, the formulation and evaluation of floating microspheres of Teneligliptin represent a promising strategy to enhance drug delivery and therapeutic efficacy in the management of type 2 diabetes mellitus. The integration of innovative formulation techniques and comprehensive evaluation methodologies underscores the potential of floating microspheres as a viable drug delivery system. Future research should focus on addressing challenges such as scalability, stability, and regulatory considerations to facilitate clinical translation and commercialization of these formulations.
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How To Cite (APA)
Dr. Roohinaz Ansari (April-2026). A Review on Floating Microspheres of Teneligliptin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 11(4), e716-e737. https://ijnrd.org/papers/IJNRD2604478.pdf
Issue
Volume 11 Issue 4, April-2026
Pages : e716-e737
Other Publication Details
Paper Reg. ID: IJNRD_323609
Published Paper Id: IJNRD2604478
Research Area: Pharmacy All
Author Type: Indian Author
Country: Bareilly , Uttar Pradesh , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2604478.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2604478
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