Paper Title
FORMULATION, DEVELOPMENT AND EVALTUATION OF APREMILAST IMMEDIATE RELEASE TABLET FOR MANAGMENT OF PSORIATIC ARTHRITIS
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Abstract
ABSTRACT: The aim of this research paper was to develop and evaluate an Apremilast immediate release tablet for the management of Psoriatic Arthritis by utilizing excipients and checking their compatibility with the API through preformulation studies. The tablets were formed using the direct compression method, and different trial batches were performed to check their activity.The preformulation studies showed that the selected excipients were compatible with the API, and the optimized formulation was found to have good flow and compressibility properties. The tablets were evaluated for their physical characteristics, including size, weight, and hardness. The in vitro dissolution studies were also conducted to assess the drug release profile of the developed tablets.The results of the study showed that the developed Apremilast immediate release tablets had excellent physical characteristics, with uniform size and weight. The in vitro dissolution studies indicated that the tablets had a quick release rate and met the required pharmacopoeial standards. The pharmacokinetic study revealed that the tablets exhibited rapid absorption, with a maximum plasma concentration achieved within 1 hour of administration.In conclusion, the developed Apremilast immediate release tablet utilizing excipients and preformulation studies has the potential to be an effective therapeutic option for the management of Psoriatic Arthritis. Further studies are required to investigate. Sometimes immediate onset of action is considered obligatory immediate release tablets are the final option. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to better patient compliance. In the present work, we engage in discussion about formulation, development, and evaluation of immediate release tablets. An immediate release dosage form allows a manufacturer to extend market exclusivity. They are also a tool for expanding markets, extending product life cycles and generating opportunities. Pharmaceutical products designed for oral delivery and currently available on the prescription and over-the-counter markets are mostly the immediate release tablet.
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How To Cite (APA)
PRIYANKA SUSHILKUMAR SARNIKAR, HINGNE L.D , & BAGWAN LATIF RASHID (June-2023). FORMULATION, DEVELOPMENT AND EVALTUATION OF APREMILAST IMMEDIATE RELEASE TABLET FOR MANAGMENT OF PSORIATIC ARTHRITIS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), 773-816. https://ijnrd.org/papers/IJNRDTH00050.pdf
Issue
Volume 8 Issue 6, June-2023
Pages : 773-816
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Paper Reg. ID: IJNRD_197500
Published Paper Id: IJNRDTH00050
Downloads: 000122018
Research Area: Pharmacy
Author Type: Foreign Author
Country: Beed, Maharashtra , India
Published Paper PDF: https://ijnrd.org/papers/IJNRDTH00050.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRDTH00050
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